New insights and challenges in mismatch repair: Getting over the chromatin hurdle

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

DNA mismatch repair (MMR) maintains genome stability primarily by repairing DNA replication-associated mispairs. Because loss of MMR function increases the mutation frequency genome-wide, defects in this pathway predispose affected individuals to cancer. The genes encoding essential eukaryotic MMR activities have been identified, as the recombinant proteins repair 'naked' heteroduplex DNA in vitro. However, the reconstituted system is inactive on nucleosome-containing heteroduplex DNA, and it is not understood how MMR occurs in vivo. Recent studies suggest that chromatin organization, nucleosome assembly/disassembly factors and histone modifications regulate MMR in eukaryotic cells, but the complexity and importance of the interaction between MMR and chromatin remodeling has only recently begun to be appreciated. This article reviews recent progress in understanding the mechanism of eukaryotic MMR in the context of chromatin structure and dynamics, considers the implications of these recent findings and discusses unresolved questions and challenges in understanding eukaryotic MMR.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalDNA Repair
Volume19
DOIs
StatePublished - Jan 1 2014

Fingerprint

DNA Mismatch Repair
Chromatin
Repair
Nucleic Acid Heteroduplexes
Nucleosomes
Histone Code
Genes
Chromatin Assembly and Disassembly
Genomic Instability
Essential Genes
Eukaryotic Cells
Gene encoding
Mutation Rate
DNA Replication
DNA
Recombinant Proteins
Histones
Genome
Defects

Keywords

  • Chromatin
  • Genetic instability
  • H3K36me3
  • Histone modification
  • Mismatch repair

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Medicine(all)

Cite this

New insights and challenges in mismatch repair : Getting over the chromatin hurdle. / Li, Guo Min.

In: DNA Repair, Vol. 19, 01.01.2014, p. 48-54.

Research output: Contribution to journalArticle

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