New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome Summary of the Aspen Lung Conference 2021

Thomas R. Martin, Rachel L. Zemans, Lorraine B. Ware, Eric P. Schmidt, David W.H. Riches, Lisa Bastarache, Carolyn S. Calfee, Tushar J. Desai, Susanne Herold, Catherine L. Hough, Mark R. Looney, Michael A. Matthay, Nuala Meyer, Samir M. Parikh, Troy Stevens, B. Taylor Thompson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Clinical and molecular heterogeneity are common features of human disease. Understanding the basis for heterogeneity has led to major advances in therapy for many cancers and pulmonary diseases such as cystic fibrosis and asthma. Although heterogeneity of risk factors, disease severity, and outcomes in survivors are common features of the acute respiratory distress syndrome (ARDS), many challenges exist in understanding the clinical and molecular basis for disease heterogeneity and using heterogeneity to tailor therapy for individual patients. This report summarizes the proceedings of the 2021 Aspen Lung Conference, which was organized to review key issues related to understanding clinical and molecular heterogeneity in ARDS. The goals were to review new information about ARDS phenotypes, to explore multicellular and multisystem mechanisms responsible for heterogeneity, and to review how best to account for clinical and molecular heterogeneity in clinical trial design and assessment of outcomes. The report concludes with recommendations for future research to understand the clinical and basic mechanisms underlying heterogeneity in ARDS to advance the development of new treatments for this life-threatening critical illness.

Original languageEnglish (US)
Pages (from-to)284-308
Number of pages25
JournalAmerican journal of respiratory cell and molecular biology
Volume67
Issue number3
DOIs
StatePublished - Sep 2022

Keywords

  • ARDS
  • biological mechanisms
  • clinical trials
  • critical care

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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