New insights into the molecular basis of the antiphospholipid syndrome

Research output: Contribution to journalReview article

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Abstract

Antiphospholipid syndrome is an autoimmune disease characterized by the presence of circulating antiphospholipid antibodies (aPL) that promote thrombosis, pregnancy complications and cardiovascular diseases. Alterations in the function of vascular cells induced by aPL underlie these outcomes. This review will discuss recent findings that indicate a novel mechanism by which aPL antagonize endothelial cell production of nitric oxide and thereby promote thrombosis.

Original languageEnglish (US)
Pages (from-to)e47-e52
JournalDrug Discovery Today: Disease Mechanisms
Volume8
Issue number1-2
DOIs
StatePublished - Jan 1 2011

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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