New insights into the molecular basis of the antiphospholipid syndrome

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Abstract

Antiphospholipid syndrome is an autoimmune disease characterized by the presence of circulating antiphospholipid antibodies (aPL) that promote thrombosis, pregnancy complications and cardiovascular diseases. Alterations in the function of vascular cells induced by aPL underlie these outcomes. This review will discuss recent findings that indicate a novel mechanism by which aPL antagonize endothelial cell production of nitric oxide and thereby promote thrombosis.

Original languageEnglish (US)
JournalDrug Discovery Today: Disease Mechanisms
Volume8
Issue number1-2
DOIs
StatePublished - Jun 2011

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Antiphospholipid Antibodies
Antiphospholipid Syndrome
Thrombosis
Pregnancy Complications
Autoimmune Diseases
Blood Vessels
Nitric Oxide
Cardiovascular Diseases
Endothelial Cells

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

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abstract = "Antiphospholipid syndrome is an autoimmune disease characterized by the presence of circulating antiphospholipid antibodies (aPL) that promote thrombosis, pregnancy complications and cardiovascular diseases. Alterations in the function of vascular cells induced by aPL underlie these outcomes. This review will discuss recent findings that indicate a novel mechanism by which aPL antagonize endothelial cell production of nitric oxide and thereby promote thrombosis.",
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