New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I

Medicine & Life Sciences

• Cytochrome P-450 CYP2C9 100%
• Cytochrome P-450 Enzyme System 73%
• Cytochrome P-450 CYP2C9 Inhibitors 19%
• Pharmaceutical Preparations 17%
• Diclofenac 12%
• Structure-Activity Relationship 12%
• Ticrynafen 9%
• Flurbiprofen 7%
• Celecoxib 6%
• Hydrogen Bonding 6%
• Ibuprofen 6%
• Retinoids 6%
• Substrate Specificity 5%
• Prodrugs 5%
• Hydrophobic and Hydrophilic Interactions 5%
• Enzymes 5%
• Melatonin 5%
• Liver 5%
• Protons 5%
• Arachidonic Acid 5%
• Drug Interactions 5%
• Drug Development 5%
• Catalytic Domain 4%
• Steroids 4%
• Poisons 3%
• Ligands 3%
• Therapeutics 1%

Chemical Compounds

• Cytochrome P450 80%
• Drug 39%
• Diclofenac 23%
• Tienilic Acid 17%
• Structure-Activity Relationship 16%
• Pharmacological Metabolism 14%
• Flurbiprofen 13%
• Celecoxib 13%
• Metabolite 13%
• Retinoid 12%
• Melatonin 12%
• Ibuprofen 10%
• Arachidonic Acid 10%
• Prodrug 10%
• pKa 9%
• Steroid 8%
• Ion Pair 8%
• Occurrence in Nature 7%
• Kd 7%
• Toxic 7%
• Hydrogen 4%
• Amount 4%
• pH Value 3%