New-onset cardiovascular morbidity in older adults with stage i to III colorectal cancer

Kelly M. Kenzik, Courtney Balentine, Joshua Richman, Meredith Kilgore, Smita Bhatia, Grant R. Williams

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose We sought to determine the long-term risk of cardiovascular disease (CVD)-stroke and myocardial infarction-and congestive heart failure (CHF) in older patients with colorectal cancer, as well as to understand the roles that preexisting comorbidities and cancer therapy play in increasing this risk. Patients and Methods We evaluated individuals from the SEER-Medicare database with incident stage I to III colorectal cancer at age older than 65 years between January 1, 2000, and December 31, 2011 (n = 72,408) and compared these patients with a matched cohort of Medicare patients without cancer (n = 72,408). Results Median age at diagnosis of colorectal cancer was 78 years (range, 66 years to 106 years), and median follow-up was 8 years since diagnosis. The 10-year cumulative incidence of new-onset CVD and CHF were 57.4% and 54.5% compared with 22% and 18% for control, respectively (P , .001). The interaction between hypertension and chemotherapy was significant (P , .001) for CVD, and that between diabetes and chemotherapy was significant (P, .001) for CHF. Within the first 2 years since diagnosis, exposure to capecitabine alone increased CHF hazard (hazard ratio [HR], 3.6; 95% CI, 12.76 to 4.38) compared with exposure to fluorouracil alone. Conversely, patients who were treated with fluorouracil alone had a higher CVD hazard at , 2 years and . 2 years since diagnosis compared with patients who received capecitabine alone (, 2 years HR, 0.63; 95% CI, 0.53 to 0.75; . 2 years HR, 0.72; 95% CI, 0.62 to 0.84). Conclusion Older patients with colorectal cancer are at increased risk of developing CVD and CHF. Diabetes and hypertension interact with chemotherapy to increase the risk of cardiovascular morbidity. Future studies should assess the potential for personalized therapeutic options for those with preexisting morbidities and for structured monitoring for patients with a history of exposure to chemotherapy regimens, as well as explore the management of preexisting comorbidities to address long-term cardiovascular morbidity.

Original languageEnglish (US)
Pages (from-to)609-616
Number of pages8
JournalJournal of Clinical Oncology
Volume36
Issue number6
DOIs
StatePublished - Feb 20 2018
Externally publishedYes

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Colorectal Neoplasms
Morbidity
Cardiovascular Diseases
Heart Failure
Drug Therapy
Medicare
Fluorouracil
Comorbidity
Myocardial Infarction
Play Therapy
Hypertension
Physiologic Monitoring
Neoplasms
Databases
Incidence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

New-onset cardiovascular morbidity in older adults with stage i to III colorectal cancer. / Kenzik, Kelly M.; Balentine, Courtney; Richman, Joshua; Kilgore, Meredith; Bhatia, Smita; Williams, Grant R.

In: Journal of Clinical Oncology, Vol. 36, No. 6, 20.02.2018, p. 609-616.

Research output: Contribution to journalArticle

Kenzik, Kelly M. ; Balentine, Courtney ; Richman, Joshua ; Kilgore, Meredith ; Bhatia, Smita ; Williams, Grant R. / New-onset cardiovascular morbidity in older adults with stage i to III colorectal cancer. In: Journal of Clinical Oncology. 2018 ; Vol. 36, No. 6. pp. 609-616.
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abstract = "Purpose We sought to determine the long-term risk of cardiovascular disease (CVD)-stroke and myocardial infarction-and congestive heart failure (CHF) in older patients with colorectal cancer, as well as to understand the roles that preexisting comorbidities and cancer therapy play in increasing this risk. Patients and Methods We evaluated individuals from the SEER-Medicare database with incident stage I to III colorectal cancer at age older than 65 years between January 1, 2000, and December 31, 2011 (n = 72,408) and compared these patients with a matched cohort of Medicare patients without cancer (n = 72,408). Results Median age at diagnosis of colorectal cancer was 78 years (range, 66 years to 106 years), and median follow-up was 8 years since diagnosis. The 10-year cumulative incidence of new-onset CVD and CHF were 57.4{\%} and 54.5{\%} compared with 22{\%} and 18{\%} for control, respectively (P , .001). The interaction between hypertension and chemotherapy was significant (P , .001) for CVD, and that between diabetes and chemotherapy was significant (P, .001) for CHF. Within the first 2 years since diagnosis, exposure to capecitabine alone increased CHF hazard (hazard ratio [HR], 3.6; 95{\%} CI, 12.76 to 4.38) compared with exposure to fluorouracil alone. Conversely, patients who were treated with fluorouracil alone had a higher CVD hazard at , 2 years and . 2 years since diagnosis compared with patients who received capecitabine alone (, 2 years HR, 0.63; 95{\%} CI, 0.53 to 0.75; . 2 years HR, 0.72; 95{\%} CI, 0.62 to 0.84). Conclusion Older patients with colorectal cancer are at increased risk of developing CVD and CHF. Diabetes and hypertension interact with chemotherapy to increase the risk of cardiovascular morbidity. Future studies should assess the potential for personalized therapeutic options for those with preexisting morbidities and for structured monitoring for patients with a history of exposure to chemotherapy regimens, as well as explore the management of preexisting comorbidities to address long-term cardiovascular morbidity.",
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T1 - New-onset cardiovascular morbidity in older adults with stage i to III colorectal cancer

AU - Kenzik, Kelly M.

AU - Balentine, Courtney

AU - Richman, Joshua

AU - Kilgore, Meredith

AU - Bhatia, Smita

AU - Williams, Grant R.

PY - 2018/2/20

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N2 - Purpose We sought to determine the long-term risk of cardiovascular disease (CVD)-stroke and myocardial infarction-and congestive heart failure (CHF) in older patients with colorectal cancer, as well as to understand the roles that preexisting comorbidities and cancer therapy play in increasing this risk. Patients and Methods We evaluated individuals from the SEER-Medicare database with incident stage I to III colorectal cancer at age older than 65 years between January 1, 2000, and December 31, 2011 (n = 72,408) and compared these patients with a matched cohort of Medicare patients without cancer (n = 72,408). Results Median age at diagnosis of colorectal cancer was 78 years (range, 66 years to 106 years), and median follow-up was 8 years since diagnosis. The 10-year cumulative incidence of new-onset CVD and CHF were 57.4% and 54.5% compared with 22% and 18% for control, respectively (P , .001). The interaction between hypertension and chemotherapy was significant (P , .001) for CVD, and that between diabetes and chemotherapy was significant (P, .001) for CHF. Within the first 2 years since diagnosis, exposure to capecitabine alone increased CHF hazard (hazard ratio [HR], 3.6; 95% CI, 12.76 to 4.38) compared with exposure to fluorouracil alone. Conversely, patients who were treated with fluorouracil alone had a higher CVD hazard at , 2 years and . 2 years since diagnosis compared with patients who received capecitabine alone (, 2 years HR, 0.63; 95% CI, 0.53 to 0.75; . 2 years HR, 0.72; 95% CI, 0.62 to 0.84). Conclusion Older patients with colorectal cancer are at increased risk of developing CVD and CHF. Diabetes and hypertension interact with chemotherapy to increase the risk of cardiovascular morbidity. Future studies should assess the potential for personalized therapeutic options for those with preexisting morbidities and for structured monitoring for patients with a history of exposure to chemotherapy regimens, as well as explore the management of preexisting comorbidities to address long-term cardiovascular morbidity.

AB - Purpose We sought to determine the long-term risk of cardiovascular disease (CVD)-stroke and myocardial infarction-and congestive heart failure (CHF) in older patients with colorectal cancer, as well as to understand the roles that preexisting comorbidities and cancer therapy play in increasing this risk. Patients and Methods We evaluated individuals from the SEER-Medicare database with incident stage I to III colorectal cancer at age older than 65 years between January 1, 2000, and December 31, 2011 (n = 72,408) and compared these patients with a matched cohort of Medicare patients without cancer (n = 72,408). Results Median age at diagnosis of colorectal cancer was 78 years (range, 66 years to 106 years), and median follow-up was 8 years since diagnosis. The 10-year cumulative incidence of new-onset CVD and CHF were 57.4% and 54.5% compared with 22% and 18% for control, respectively (P , .001). The interaction between hypertension and chemotherapy was significant (P , .001) for CVD, and that between diabetes and chemotherapy was significant (P, .001) for CHF. Within the first 2 years since diagnosis, exposure to capecitabine alone increased CHF hazard (hazard ratio [HR], 3.6; 95% CI, 12.76 to 4.38) compared with exposure to fluorouracil alone. Conversely, patients who were treated with fluorouracil alone had a higher CVD hazard at , 2 years and . 2 years since diagnosis compared with patients who received capecitabine alone (, 2 years HR, 0.63; 95% CI, 0.53 to 0.75; . 2 years HR, 0.72; 95% CI, 0.62 to 0.84). Conclusion Older patients with colorectal cancer are at increased risk of developing CVD and CHF. Diabetes and hypertension interact with chemotherapy to increase the risk of cardiovascular morbidity. Future studies should assess the potential for personalized therapeutic options for those with preexisting morbidities and for structured monitoring for patients with a history of exposure to chemotherapy regimens, as well as explore the management of preexisting comorbidities to address long-term cardiovascular morbidity.

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