New-onset diabetes after androgen-deprivation therapy for prostate cancer: A nationwide propensity score-matched four-year longitudinal cohort study

Jhen Hao Jhan, Hsin Chih Yeh, Yu Han Chang, Shiao Jin Guu, Wen Jeng Wu, Yii Her Chou, Ching Chia Li

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Introduction: Androgen-deprivation therapy (ADT) is important in the treatment of prostate cancer. However, the relationship between ADT and the risk of diabetes remains unclear, and the association between duration and types of ADT has not been fully investigated. Aim: To examine the risk of developing type 2 diabetes mellitus (T2DM) in men who underwent ADT for prostate cancer. Methods: Data were collected retrospectively from the Longitudinal Health Insurance Database of Taiwan. In total, 4604 prostate cancer patients ≥40 years old who underwent ADT were included in the study cohort, and 4604 prostate cancer patients without ADT were included as controls, after adjusting for age and other comorbidities. Results: During the four-year follow-up period, the incidence of new-onset T2DM was 27.49 and 11.13 per 1000 person-years in the ADT and ADT-never cohorts, respectively. The ADT cohort was 2.19 times more likely to develop T2DM than the control group (95% CI 1.90–2.53, P < 0.001). Furthermore, the association was particularly striking in the subgroup of patients receiving complete androgen blockade (adjusted HR 2.33, 95% CI 1.96–2.78, P < 0.001). Conclusions: Men with prostate cancer who received ADT are at risk for developing diabetes.

Original languageEnglish (US)
Pages (from-to)688-692
Number of pages5
JournalJournal of Diabetes and Its Complications
Volume32
Issue number7
DOIs
StatePublished - Jul 2018
Externally publishedYes

Keywords

  • Androgen-deprivation therapy
  • Complete Androgen Blockade (CAB)
  • Insulin deficiency
  • Insulin resistance
  • Prostate cancer
  • Type 2 diabetes (T2DM)

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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