TY - JOUR
T1 - New roles of the Na+/H+exchange regulatory factor 1 scaffolding protein
T2 - A review
AU - Bushau-Sprinkle, Adrienne M.
AU - Lederer, Eleanor D.
N1 - Publisher Copyright:
© 2020 American Physiological Society. All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - New roles of the Na+/H+ exchange regulatory factor 1 scaffolding protein: A review. Am J Physiol Renal Physiol 318: F804-F808, 2020. First published January 27, 2020; doi:10.1152/ajprenal.00467. 2019.-Na+/H+ exchange regulatory factor 1 (NHERF1), a member of a PDZ scaffolding protein family, was first identified as an organizer of membrane-bound protein complexes composed of hormone receptors, signal transduction pathways, and electrolyte and mineral transporters and channels. NHERF1 is involved in the regulation of Na+/H+ exchanger 3, Na+-dependent phosphate transporter 2a, and Na+-K+-ATPase through its ability to scaffold these transporters to the plasma membrane, allowing regulation of these protein complexes with their associated hormone receptors. Recently, NHERF1 has received increased interest in its involvement in a variety of functions, including cell structure and trafficking, tumorigenesis and tumor behavior, inflammatory responses, and tissue injury. In this review, we highlight the evidence for the expansive role of NHERF1 in cell biology and speculate on the implications for renal physiology and pathophysiology.
AB - New roles of the Na+/H+ exchange regulatory factor 1 scaffolding protein: A review. Am J Physiol Renal Physiol 318: F804-F808, 2020. First published January 27, 2020; doi:10.1152/ajprenal.00467. 2019.-Na+/H+ exchange regulatory factor 1 (NHERF1), a member of a PDZ scaffolding protein family, was first identified as an organizer of membrane-bound protein complexes composed of hormone receptors, signal transduction pathways, and electrolyte and mineral transporters and channels. NHERF1 is involved in the regulation of Na+/H+ exchanger 3, Na+-dependent phosphate transporter 2a, and Na+-K+-ATPase through its ability to scaffold these transporters to the plasma membrane, allowing regulation of these protein complexes with their associated hormone receptors. Recently, NHERF1 has received increased interest in its involvement in a variety of functions, including cell structure and trafficking, tumorigenesis and tumor behavior, inflammatory responses, and tissue injury. In this review, we highlight the evidence for the expansive role of NHERF1 in cell biology and speculate on the implications for renal physiology and pathophysiology.
KW - Cell biology
KW - Function
KW - Na+/H+ exchange regulatory factor 1
KW - Renal physiology and pathophysiology
UR - http://www.scopus.com/inward/record.url?scp=85081946022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85081946022&partnerID=8YFLogxK
U2 - 10.1152/AJPRENAL.00467.2019
DO - 10.1152/AJPRENAL.00467.2019
M3 - Review article
C2 - 31984791
AN - SCOPUS:85081946022
SN - 1931-857X
VL - 318
SP - F804-F808
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
IS - 3
ER -