New roles of the Na+/H+exchange regulatory factor 1 scaffolding protein: A review

Adrienne M. Bushau-Sprinkle, Eleanor D. Lederer

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


New roles of the Na+/H+ exchange regulatory factor 1 scaffolding protein: A review. Am J Physiol Renal Physiol 318: F804-F808, 2020. First published January 27, 2020; doi:10.1152/ajprenal.00467. 2019.-Na+/H+ exchange regulatory factor 1 (NHERF1), a member of a PDZ scaffolding protein family, was first identified as an organizer of membrane-bound protein complexes composed of hormone receptors, signal transduction pathways, and electrolyte and mineral transporters and channels. NHERF1 is involved in the regulation of Na+/H+ exchanger 3, Na+-dependent phosphate transporter 2a, and Na+-K+-ATPase through its ability to scaffold these transporters to the plasma membrane, allowing regulation of these protein complexes with their associated hormone receptors. Recently, NHERF1 has received increased interest in its involvement in a variety of functions, including cell structure and trafficking, tumorigenesis and tumor behavior, inflammatory responses, and tissue injury. In this review, we highlight the evidence for the expansive role of NHERF1 in cell biology and speculate on the implications for renal physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)F804-F808
JournalAmerican Journal of Physiology - Renal Physiology
Issue number3
StatePublished - Mar 2020
Externally publishedYes


  • Cell biology
  • Function
  • Na+/H+ exchange regulatory factor 1
  • Renal physiology and pathophysiology

ASJC Scopus subject areas

  • Physiology
  • Urology


Dive into the research topics of 'New roles of the Na+/H+exchange regulatory factor 1 scaffolding protein: A review'. Together they form a unique fingerprint.

Cite this