TY - JOUR
T1 - New therapeutic targets for cancer bone metastasis
AU - Krzeszinski, Jing Y.
AU - Wan, Yihong
N1 - Funding Information:
We thank all the investigators whose studies have contributed to the understanding of cancer bone metastasis but could not be cited here due to space limitation. Y.W. is a Virginia Murchison Linthicum Scholar in Medical Research. This work was supported in part by the Cancer Prevention Research Institute of Texas (CPRIT) (RP130145, Y.W.), the US Department of Defense (W81XWH-13-1-0318, Y.W.), National Institutes of Health (NIH, R01DK089113, Y.W.), Mary Kay Foundation (#073.14, Y.W.), Simmons Cancer Center (Y.W.), Welch Foundation (I-1751, Y.W.), UT Southwestern Endowed Scholar Startup Fund (Y.W.), NIH T32 Training Grant (J.Y.K.), and a National Cancer Institute (NCI) Cancer Center Support Grant (5P30CA142543).
Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Bone metastases are dejected consequences of many types of tumors including breast, prostate, lung, kidney, and thyroid cancers. This complicated process begins with the successful tumor cell epithelial-mesenchymal transition, escape from the original site, and penetration into the circulation. The homing of tumor cells to the bone depends on both tumor-intrinsic traits and various molecules supplied by the bone metastatic niche. The colonization and growth of cancer cells in the osseous environment, which awaken their dormancy to form micro- and macro-metastasis, involve an intricate interaction between the circulating tumor cells and local bone cells including osteoclasts, osteoblasts, adipocytes, and macrophages. We discuss the most recent advances in the identification of new molecules and novel mechanisms during each step of bone metastasis that may serve as promising therapeutic targets.
AB - Bone metastases are dejected consequences of many types of tumors including breast, prostate, lung, kidney, and thyroid cancers. This complicated process begins with the successful tumor cell epithelial-mesenchymal transition, escape from the original site, and penetration into the circulation. The homing of tumor cells to the bone depends on both tumor-intrinsic traits and various molecules supplied by the bone metastatic niche. The colonization and growth of cancer cells in the osseous environment, which awaken their dormancy to form micro- and macro-metastasis, involve an intricate interaction between the circulating tumor cells and local bone cells including osteoclasts, osteoblasts, adipocytes, and macrophages. We discuss the most recent advances in the identification of new molecules and novel mechanisms during each step of bone metastasis that may serve as promising therapeutic targets.
KW - Bone metastatic niche
KW - Bone microenvironment
KW - Macrometastasis
KW - Osteoblast
KW - Osteoclast
KW - Tumor-intrinsic factors
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U2 - 10.1016/j.tips.2015.04.006
DO - 10.1016/j.tips.2015.04.006
M3 - Review article
C2 - 25962679
AN - SCOPUS:84934923163
SN - 0165-6147
VL - 36
SP - 360
EP - 373
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 6
ER -