Newer glycopeptide antibiotics for treatment of complicated skin and soft tissue infections: systematic review, network meta-analysis and cost analysis

R. Agarwal, S. M. Bartsch, B. J. Kelly, M. Prewitt, Y. Liu, Y. Chen, C. A. Umscheid

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Objectives: Skin and soft tissue infections (SSTIs) carry significant economic burden, as well as morbidity and mortality, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Several new MRSA-active antibiotics have been developed, including semisynthetic glycopeptides (telavancin, dalbavancin and oritavancin). Of these, dalbavancin and oritavancin offer extended dosing intervals. Methods: We performed a systematic review, network meta-analysis and cost analysis to compare the newer glycopeptides to standard care and to each other for the treatment of complicated SSTIs (cSSTI). A search for randomized controlled trials (RCTs) was conducted in Medline, Embase and the Cochrane Central Register of Controlled Trials. We also developed a model to evaluate the costs associated with dalbavancin and oritavancin from the third-party payer perspective. Results: Seven RCTs met the inclusion criteria. Network meta-analyses suggested that the clinical response to telavancin, dalbavancin and oritavancin was similar to standard care (odds ratio (OR) 1.09, 95% confidence interval (CI) 0.90–1.33; OR 0.78, 95% CI 0.52–1.18; and OR 1.06, 95% CI 0.85–1.33, respectively). Head-to-head comparisons showed no difference in clinical response between oritavancin and dalbavancin (OR 1.36; 95% CI 0.85–2.18), oritavancin and telavancin (OR 0.98; 95% CI 0.72–1.31) or dalbavancin and telavancin (OR 0.72; 95% CI 0.45–1.13). Telavancin had a higher incidence of overall adverse events compared to standard care (OR 1.33; 95% CI 1.10–1.61). Compared to telavancin, there were fewer overall adverse events with dalbavancin (OR 0.58; 95% CI 0.45–0.76) and oritavancin (OR 0.71; 95% CI 0.55–0.92). Studies were of high quality overall. Our cost analyses demonstrated that dalbavancin and oritavancin were less costly compared to standard care under baseline assumptions and many scenarios evaluated. The use of dalbavancin could save third-party payers $1442 to $4803 per cSSTI, while the use of oritavancin could save $3571 to $6932 per cSSTI. Conclusions: Dalbavancin and oritavancin demonstrate efficacy and safety comparable to standard care in well-designed RCTs and result in cost savings when standard care is treatment that covers MRSA.

Original languageEnglish (US)
Pages (from-to)361-368
Number of pages8
JournalClinical Microbiology and Infection
Volume24
Issue number4
DOIs
StatePublished - Apr 2018
Externally publishedYes

Fingerprint

oritavancin
Soft Tissue Infections
Glycopeptides
Anti-Bacterial Agents
Odds Ratio
Costs and Cost Analysis
Confidence Intervals
Skin
Methicillin-Resistant Staphylococcus aureus
Health Insurance Reimbursement
Randomized Controlled Trials
Network Meta-Analysis
dalbavancin
Cost Savings

Keywords

  • Cost analysis
  • Dalbavancin
  • Meta-analysis
  • Oritavancin
  • Systematic review

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Newer glycopeptide antibiotics for treatment of complicated skin and soft tissue infections : systematic review, network meta-analysis and cost analysis. / Agarwal, R.; Bartsch, S. M.; Kelly, B. J.; Prewitt, M.; Liu, Y.; Chen, Y.; Umscheid, C. A.

In: Clinical Microbiology and Infection, Vol. 24, No. 4, 04.2018, p. 361-368.

Research output: Contribution to journalReview article

Agarwal, R. ; Bartsch, S. M. ; Kelly, B. J. ; Prewitt, M. ; Liu, Y. ; Chen, Y. ; Umscheid, C. A. / Newer glycopeptide antibiotics for treatment of complicated skin and soft tissue infections : systematic review, network meta-analysis and cost analysis. In: Clinical Microbiology and Infection. 2018 ; Vol. 24, No. 4. pp. 361-368.
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abstract = "Objectives: Skin and soft tissue infections (SSTIs) carry significant economic burden, as well as morbidity and mortality, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Several new MRSA-active antibiotics have been developed, including semisynthetic glycopeptides (telavancin, dalbavancin and oritavancin). Of these, dalbavancin and oritavancin offer extended dosing intervals. Methods: We performed a systematic review, network meta-analysis and cost analysis to compare the newer glycopeptides to standard care and to each other for the treatment of complicated SSTIs (cSSTI). A search for randomized controlled trials (RCTs) was conducted in Medline, Embase and the Cochrane Central Register of Controlled Trials. We also developed a model to evaluate the costs associated with dalbavancin and oritavancin from the third-party payer perspective. Results: Seven RCTs met the inclusion criteria. Network meta-analyses suggested that the clinical response to telavancin, dalbavancin and oritavancin was similar to standard care (odds ratio (OR) 1.09, 95{\%} confidence interval (CI) 0.90–1.33; OR 0.78, 95{\%} CI 0.52–1.18; and OR 1.06, 95{\%} CI 0.85–1.33, respectively). Head-to-head comparisons showed no difference in clinical response between oritavancin and dalbavancin (OR 1.36; 95{\%} CI 0.85–2.18), oritavancin and telavancin (OR 0.98; 95{\%} CI 0.72–1.31) or dalbavancin and telavancin (OR 0.72; 95{\%} CI 0.45–1.13). Telavancin had a higher incidence of overall adverse events compared to standard care (OR 1.33; 95{\%} CI 1.10–1.61). Compared to telavancin, there were fewer overall adverse events with dalbavancin (OR 0.58; 95{\%} CI 0.45–0.76) and oritavancin (OR 0.71; 95{\%} CI 0.55–0.92). Studies were of high quality overall. Our cost analyses demonstrated that dalbavancin and oritavancin were less costly compared to standard care under baseline assumptions and many scenarios evaluated. The use of dalbavancin could save third-party payers $1442 to $4803 per cSSTI, while the use of oritavancin could save $3571 to $6932 per cSSTI. Conclusions: Dalbavancin and oritavancin demonstrate efficacy and safety comparable to standard care in well-designed RCTs and result in cost savings when standard care is treatment that covers MRSA.",
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TY - JOUR

T1 - Newer glycopeptide antibiotics for treatment of complicated skin and soft tissue infections

T2 - systematic review, network meta-analysis and cost analysis

AU - Agarwal, R.

AU - Bartsch, S. M.

AU - Kelly, B. J.

AU - Prewitt, M.

AU - Liu, Y.

AU - Chen, Y.

AU - Umscheid, C. A.

PY - 2018/4

Y1 - 2018/4

N2 - Objectives: Skin and soft tissue infections (SSTIs) carry significant economic burden, as well as morbidity and mortality, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Several new MRSA-active antibiotics have been developed, including semisynthetic glycopeptides (telavancin, dalbavancin and oritavancin). Of these, dalbavancin and oritavancin offer extended dosing intervals. Methods: We performed a systematic review, network meta-analysis and cost analysis to compare the newer glycopeptides to standard care and to each other for the treatment of complicated SSTIs (cSSTI). A search for randomized controlled trials (RCTs) was conducted in Medline, Embase and the Cochrane Central Register of Controlled Trials. We also developed a model to evaluate the costs associated with dalbavancin and oritavancin from the third-party payer perspective. Results: Seven RCTs met the inclusion criteria. Network meta-analyses suggested that the clinical response to telavancin, dalbavancin and oritavancin was similar to standard care (odds ratio (OR) 1.09, 95% confidence interval (CI) 0.90–1.33; OR 0.78, 95% CI 0.52–1.18; and OR 1.06, 95% CI 0.85–1.33, respectively). Head-to-head comparisons showed no difference in clinical response between oritavancin and dalbavancin (OR 1.36; 95% CI 0.85–2.18), oritavancin and telavancin (OR 0.98; 95% CI 0.72–1.31) or dalbavancin and telavancin (OR 0.72; 95% CI 0.45–1.13). Telavancin had a higher incidence of overall adverse events compared to standard care (OR 1.33; 95% CI 1.10–1.61). Compared to telavancin, there were fewer overall adverse events with dalbavancin (OR 0.58; 95% CI 0.45–0.76) and oritavancin (OR 0.71; 95% CI 0.55–0.92). Studies were of high quality overall. Our cost analyses demonstrated that dalbavancin and oritavancin were less costly compared to standard care under baseline assumptions and many scenarios evaluated. The use of dalbavancin could save third-party payers $1442 to $4803 per cSSTI, while the use of oritavancin could save $3571 to $6932 per cSSTI. Conclusions: Dalbavancin and oritavancin demonstrate efficacy and safety comparable to standard care in well-designed RCTs and result in cost savings when standard care is treatment that covers MRSA.

AB - Objectives: Skin and soft tissue infections (SSTIs) carry significant economic burden, as well as morbidity and mortality, especially when caused by methicillin-resistant Staphylococcus aureus (MRSA). Several new MRSA-active antibiotics have been developed, including semisynthetic glycopeptides (telavancin, dalbavancin and oritavancin). Of these, dalbavancin and oritavancin offer extended dosing intervals. Methods: We performed a systematic review, network meta-analysis and cost analysis to compare the newer glycopeptides to standard care and to each other for the treatment of complicated SSTIs (cSSTI). A search for randomized controlled trials (RCTs) was conducted in Medline, Embase and the Cochrane Central Register of Controlled Trials. We also developed a model to evaluate the costs associated with dalbavancin and oritavancin from the third-party payer perspective. Results: Seven RCTs met the inclusion criteria. Network meta-analyses suggested that the clinical response to telavancin, dalbavancin and oritavancin was similar to standard care (odds ratio (OR) 1.09, 95% confidence interval (CI) 0.90–1.33; OR 0.78, 95% CI 0.52–1.18; and OR 1.06, 95% CI 0.85–1.33, respectively). Head-to-head comparisons showed no difference in clinical response between oritavancin and dalbavancin (OR 1.36; 95% CI 0.85–2.18), oritavancin and telavancin (OR 0.98; 95% CI 0.72–1.31) or dalbavancin and telavancin (OR 0.72; 95% CI 0.45–1.13). Telavancin had a higher incidence of overall adverse events compared to standard care (OR 1.33; 95% CI 1.10–1.61). Compared to telavancin, there were fewer overall adverse events with dalbavancin (OR 0.58; 95% CI 0.45–0.76) and oritavancin (OR 0.71; 95% CI 0.55–0.92). Studies were of high quality overall. Our cost analyses demonstrated that dalbavancin and oritavancin were less costly compared to standard care under baseline assumptions and many scenarios evaluated. The use of dalbavancin could save third-party payers $1442 to $4803 per cSSTI, while the use of oritavancin could save $3571 to $6932 per cSSTI. Conclusions: Dalbavancin and oritavancin demonstrate efficacy and safety comparable to standard care in well-designed RCTs and result in cost savings when standard care is treatment that covers MRSA.

KW - Cost analysis

KW - Dalbavancin

KW - Meta-analysis

KW - Oritavancin

KW - Systematic review

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