TY - JOUR
T1 - Newly discovered respiratory viruses
T2 - significance and implications
AU - Kahn, Jeffrey
PY - 2007/10
Y1 - 2007/10
N2 - With the recent advances in molecular biology and the ability to amplify viral genomes in a non-sequence-dependent manner, several previously unidentified human respiratory viruses have been discovered. There are accumulating data that some of these new pathogens are responsible for a substantial proportion of respiratory tract diseases, particularly in children. This review will focus on several of these newly identified pathogens for which there are clinical data implicating a role of these viruses in respiratory tract disease specifically, human metapneumovirus, human coronaviruses NL63 and HKU1, and the human bocavirus. Antivirals and effective vaccines for these new agents may decrease the burden of respiratory tract diseases.
AB - With the recent advances in molecular biology and the ability to amplify viral genomes in a non-sequence-dependent manner, several previously unidentified human respiratory viruses have been discovered. There are accumulating data that some of these new pathogens are responsible for a substantial proportion of respiratory tract diseases, particularly in children. This review will focus on several of these newly identified pathogens for which there are clinical data implicating a role of these viruses in respiratory tract disease specifically, human metapneumovirus, human coronaviruses NL63 and HKU1, and the human bocavirus. Antivirals and effective vaccines for these new agents may decrease the burden of respiratory tract diseases.
UR - http://www.scopus.com/inward/record.url?scp=35248882909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35248882909&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2007.07.004
DO - 10.1016/j.coph.2007.07.004
M3 - Review article
C2 - 17689145
AN - SCOPUS:35248882909
SN - 1471-4892
VL - 7
SP - 478
EP - 483
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 5
ER -