NHX-5, Anl endosomal Na+/H+ exchanger, is associated with metformin action

Jeongho Kim; Hye Yeon Lee; Jheesoo Ahn; Moonjung Hyun; Inhwan Lee; Kyung Jin Min; Young Jai You

doi:10.1074/jbc.C116.744037

NHX-5, Anl endosomal Na⁺/H⁺ exchanger, is associated with metformin action

Jeongho Kim, Hye Yeon Lee, Jheesoo Ahn, Moonjung Hyun, Inhwan Lee, Kyung Jin Min, Young Jai You

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na⁺/H⁺ exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.

Original language	English (US)
Pages (from-to)	18591-18599
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	291
Issue number	35
DOIs	https://doi.org/10.1074/jbc.C116.744037
State	Published - Aug 26 2016
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "NHX-5, Anl endosomal Na+/H+ exchanger, is associated with metformin action",

abstract = "Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na+/H+ exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.",

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AU - Lee, Hye Yeon

AU - Ahn, Jheesoo

AU - Hyun, Moonjung

AU - Lee, Inhwan

AU - Min, Kyung Jin

AU - You, Young Jai

PY - 2016/8/26

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AB - Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na+/H+ exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.

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NHX-5, Anl endosomal Na⁺/H⁺ exchanger, is associated with metformin action

Abstract

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