Nickel-catalyzed carbonylative Negishi cross-coupling reactions

Qiaoling Wang, Chuo Chen

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Catalytic carbonylative Negishi cross-coupling reactions are described. This method readily provides various enones from enol triflates and diorganozinc reagents with catalytic amounts of nickel(II) chloride-4,4′-dimethoxyl-2,2′-bipyridyl under carbon monoxide atmosphere. The rate of carbon monoxide insertion is increased by the addition of lithium or magnesium halides and the use of polar solvents. Alkenyl iodides can also be used in place of enol triflates.

Original languageEnglish (US)
Pages (from-to)2916-2921
Number of pages6
JournalTetrahedron Letters
Volume49
Issue number18
DOIs
StatePublished - Apr 28 2008

Keywords

  • Carbonylative cross-coupling
  • Enone
  • Negishi reaction
  • Nickel catalysis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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