NICOTINIC ACETYLCHOLINE RECEPTOR OF MAMMALIAN BRAIN: NAJA TOXIN BINDING TO SUBCELLULAR FRACTIONS OF RAT BRAIN

R. S A Tindall, M. Kent, F. Baskin, R. N. Rosenberg

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Abstract— Subcellular fractions of rat brain cortex bound 6.8 ± 0.4 fmol of 125I‐labeled α‐naja toxin per milligram of protein. Toxin binding was saturable and specific e.g. nicotinic agonist and antagonist blockable. Regions in rat brain varied in saturable, specific toxin binding with hippocampus, olfactory area and corpus striatum displaying greatest toxin binding. We conclude that 125I‐α‐naja toxin is a suitable probe for nicotinic cholinergic receptor in brain.

Original languageEnglish (US)
Pages (from-to)859-863
Number of pages5
JournalJournal of Neurochemistry
Volume30
Issue number4
DOIs
StatePublished - Apr 1978

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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