Nitric oxide, proteasomal function, and iron homeostasis - Implications in aging and neurodegenerative diseases

Srigiridhar Kotamraju, Shasi Kalivendi, Tiesong Shang, B. Kalyanaraman

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

In this chapter, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to oxidants. The role of nitric oxide in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications.

Original languageEnglish (US)
Pages (from-to)526-534
Number of pages9
JournalMethods in Enzymology
Volume396
DOIs
StatePublished - Jan 1 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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