TY - JOUR
T1 - Nitric oxide, proteasomal function, and iron homeostasis - Implications in aging and neurodegenerative diseases
AU - Kotamraju, Srigiridhar
AU - Kalivendi, Shasi
AU - Shang, Tiesong
AU - Kalyanaraman, B.
N1 - Funding Information:
This work was supported by National Institutes of Health grants HL073056‐01 and HL68769‐01.
PY - 2005
Y1 - 2005
N2 - In this chapter, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to oxidants. The role of nitric oxide in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications.
AB - In this chapter, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to oxidants. The role of nitric oxide in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications.
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U2 - 10.1016/S0076-6879(05)96044-8
DO - 10.1016/S0076-6879(05)96044-8
M3 - Review article
C2 - 16291259
AN - SCOPUS:27744520419
SN - 0076-6879
VL - 396
SP - 526
EP - 534
JO - Methods in Enzymology
JF - Methods in Enzymology
ER -