Nitric oxide synthesis from L-arginine modulates renal vascular resistance in isolated perfused and intact rat kidneys

W. J. Welch, C. S. Wilcox, K. Aisaka, S. S. Gross, O. W. Griffith, B. M A Fontoura, T. Maack, R. Levi

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

This study tested the effects on renal hemodynamics of blockade of nitric oxide (NO) synthesis from L-arginine with N(G)-methyl-L-arginine (L-NMA) using both intact and isolated perfused rat kidneys. Infusion of L-NMA into anesthetized rats increased the mean arterial pressure and reduced the glomerular filtration rate and renal plasma flow only when the renal perfusion pressure was maintained at control levels. In isolated kidneys, L-NMA increased vascular resistance; this was attenuated by coadministration of L-arginine. L-NMA selectively inhibited acetylcholine-induced renal vasodilation without attenuating that elicited by sodium nitroprusside. We conclude that basal production of NO within both the intact and isolated kidney is required to maintain the normally high levels of renal blood flow and glomerular filtration and that endothelium-derived NO is an important regulator of renal vascular resistance.

Original languageEnglish (US)
Pages (from-to)S165-S168
JournalJournal of Cardiovascular Pharmacology
Volume17
Issue numberSUPPL. 3
DOIs
StatePublished - Jan 1 1991

Keywords

  • L-NMA
  • Rat kidney
  • Renal hemodynamics

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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