NMDA-dependent modulation of CA1 local circuit inhibition

Heinz C R Grunze, Donald G. Rainnie, Michael E. Hasselmo, Eddie Barkai, Elizabeth F. Hearn, Robert W. McCarley, Robert W. Greene

Research output: Contribution to journalArticle

348 Citations (Scopus)

Abstract

Whole-cell and extracellular recording techniques were used to examine local circuit inhibition in the CA1 region of the rat hippocampus in vitro. Activation, primarily of the recurrent inhibitory circuit by alvear stimulation, elicited an IPSP in pyramidal neurons that was dependent, in part, on NMDA receptor activation. Application of a tetanizing stimulus to the alveus evoked long-term potentiation (LTP) of the intracellularly recorded recurrent IPSPs. This LTP also was NMDA-dependent and was more sensitive to blockade by the NMDA antagonists 2-amino-5-phosphonovalerate (APV) and N-acetyl-aspartyl-glutamate, than the excitatory LTP produced by Schaffer collateral stimulation. With regard to APV, the sensitivity of inhibitory LTP was an order of magnitude greater. A biophysical simulation of hippocampal CA1 circuitry was used in a model of learned pattern recognition that included LTP in both excitatory and inhibitory recurrent circuits. In this model, selective blockade of inhibitory LTP produced aberrant spread of lateral excitation, resulting in confusion of normally distinguishable patterns of neuronal activity. Consideration is given to the possibility that selective disruption of NMDA-dependent modulation of local circuit inhibition may serve as a model for some aspects of dysfunction associated with NMDA- antagonist exposure and schizophrenia.

Original languageEnglish (US)
Pages (from-to)2034-2043
Number of pages10
JournalJournal of Neuroscience
Volume16
Issue number6
StatePublished - Mar 15 1996

Fingerprint

Long-Term Potentiation
N-Methylaspartate
Inhibitory Postsynaptic Potentials
Hippocampus
2-Amino-5-phosphonovalerate
Confusion
Pyramidal Cells
Patch-Clamp Techniques
N-Methyl-D-Aspartate Receptors
Inhibition (Psychology)
Schizophrenia

Keywords

  • AP5
  • long-term potentiation
  • N- acetylaspartyl-glutamate
  • phencyclidine
  • recurrent inhibition
  • schizophrenia
  • signal processing

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Grunze, H. C. R., Rainnie, D. G., Hasselmo, M. E., Barkai, E., Hearn, E. F., McCarley, R. W., & Greene, R. W. (1996). NMDA-dependent modulation of CA1 local circuit inhibition. Journal of Neuroscience, 16(6), 2034-2043.

NMDA-dependent modulation of CA1 local circuit inhibition. / Grunze, Heinz C R; Rainnie, Donald G.; Hasselmo, Michael E.; Barkai, Eddie; Hearn, Elizabeth F.; McCarley, Robert W.; Greene, Robert W.

In: Journal of Neuroscience, Vol. 16, No. 6, 15.03.1996, p. 2034-2043.

Research output: Contribution to journalArticle

Grunze, HCR, Rainnie, DG, Hasselmo, ME, Barkai, E, Hearn, EF, McCarley, RW & Greene, RW 1996, 'NMDA-dependent modulation of CA1 local circuit inhibition', Journal of Neuroscience, vol. 16, no. 6, pp. 2034-2043.
Grunze HCR, Rainnie DG, Hasselmo ME, Barkai E, Hearn EF, McCarley RW et al. NMDA-dependent modulation of CA1 local circuit inhibition. Journal of Neuroscience. 1996 Mar 15;16(6):2034-2043.
Grunze, Heinz C R ; Rainnie, Donald G. ; Hasselmo, Michael E. ; Barkai, Eddie ; Hearn, Elizabeth F. ; McCarley, Robert W. ; Greene, Robert W. / NMDA-dependent modulation of CA1 local circuit inhibition. In: Journal of Neuroscience. 1996 ; Vol. 16, No. 6. pp. 2034-2043.
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