NMR Temperature Measurements Using a Paramagnetic Lanthanide Complex

C. S. Zuo, K. R. Metz, Y. Sun, A. D. Sherry

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

NMR thermometry has previously suffered from poor thermal resolution owing to the relatively weak dependence of chemical shift on temperature in diamagnetic molecules. In contrast, the shifts of nuclear spins near a paramagnetic center exhibit strong temperature dependencies. The chemical shifts of the thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) complex (TmDOTP5-) have been studied as a function of temperature, pH, and Ca2+ concentration over ranges which may be encountered in vivo. The results demonstrate that the 1H and 31P shifts in TmDOTP5- are highly sensitive to temperature and may be used for NMR thermometry with excellent accuracy and resolution. A new technique is also described which permits simultaneous measurements of temperature and pH changes from the shifts of multiple TmDOTP5- spectral lines.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalJournal of Magnetic Resonance
Volume133
Issue number1
StatePublished - Jul 1998

Fingerprint

Lanthanoid Series Elements
Temperature measurement
temperature measurement
Nuclear magnetic resonance
nuclear magnetic resonance
Temperature
Thermometry
Chemical shift
chemical equilibrium
shift
Thulium
temperature
Organophosphonates
thulium
methylene
nuclear spin
line spectra
Hot Temperature
Molecules
molecules

Keywords

  • Chemical shift
  • NMR temperature measurement
  • Paramagnetic thermometric substance
  • pH dependence
  • TmDOTP

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

NMR Temperature Measurements Using a Paramagnetic Lanthanide Complex. / Zuo, C. S.; Metz, K. R.; Sun, Y.; Sherry, A. D.

In: Journal of Magnetic Resonance, Vol. 133, No. 1, 07.1998, p. 53-60.

Research output: Contribution to journalArticle

Zuo, C. S. ; Metz, K. R. ; Sun, Y. ; Sherry, A. D. / NMR Temperature Measurements Using a Paramagnetic Lanthanide Complex. In: Journal of Magnetic Resonance. 1998 ; Vol. 133, No. 1. pp. 53-60.
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