NMR Temperature Measurements Using a Paramagnetic Lanthanide Complex

C. S. Zuo, K. R. Metz, Y. Sun, A. D. Sherry

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

NMR thermometry has previously suffered from poor thermal resolution owing to the relatively weak dependence of chemical shift on temperature in diamagnetic molecules. In contrast, the shifts of nuclear spins near a paramagnetic center exhibit strong temperature dependencies. The chemical shifts of the thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) complex (TmDOTP5-) have been studied as a function of temperature, pH, and Ca2+ concentration over ranges which may be encountered in vivo. The results demonstrate that the 1H and 31P shifts in TmDOTP5- are highly sensitive to temperature and may be used for NMR thermometry with excellent accuracy and resolution. A new technique is also described which permits simultaneous measurements of temperature and pH changes from the shifts of multiple TmDOTP5- spectral lines.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalJournal of Magnetic Resonance
Volume133
Issue number1
DOIs
StatePublished - Jul 1998

Keywords

  • Chemical shift
  • NMR temperature measurement
  • Paramagnetic thermometric substance
  • TmDOTP
  • pH dependence

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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