TY - JOUR
T1 - No cerebral or cervical venous insufficiency in US veterans with multiple sclerosis
AU - Marder, Ellen J
AU - Gupta, Pramod
AU - Greenberg, Benjamin
AU - Frohman, Elliot
AU - Awad, Amer M.
AU - Bagert, Bridget
AU - Stuve, Olaf
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12
Y1 - 2011/12
N2 - Objective: To determine if chronic cerebral venous insufficiency exists in patients with multiple sclerosis (MS) using ultrasonography and 4-dimensional color Doppler ultrasonography examination and unverified criteria proposed by Zamboni et al. Design: Patients with MS and clinically isolated syndrome were matched by age and sex with subjects with migraine or no neurological disease. All subjects underwent gray-scale, color, and spectral Doppler ultrasonography examination of the internal jugular veins (IJVs), vertebral veins, and deep cerebral veins for stenosis, absence of signal, and reflux. Setting: Academic MS center. Patients: All patients with MS fulfilled revised McDonald criteria for the diagnosis of MS. Patients with clinically isolated syndrome exhibited a typical transient focal neurological deficit and had magnetic resonance imaging lesions typical of MS. Control subjects were recruited from the VA migraine clinic or staff. Main Outcome Measures: Five parameters of venous outflow used by Zamboni et al. were examined: (1) IJV or vertebral vein reflux, (2) deep cerebral vein reflux, (3) IJV stenosis, (4) absence of flow in IJVs or vertebral veins, and (5) change in cross-sectional area of the IJV with postural change. Results: There was no significant difference in the number and type of venous outflow abnormalities in patients with MS compared with controls. Conclusion: This study does not support the theory that chronic cerebral venous insufficiency exists in MS.
AB - Objective: To determine if chronic cerebral venous insufficiency exists in patients with multiple sclerosis (MS) using ultrasonography and 4-dimensional color Doppler ultrasonography examination and unverified criteria proposed by Zamboni et al. Design: Patients with MS and clinically isolated syndrome were matched by age and sex with subjects with migraine or no neurological disease. All subjects underwent gray-scale, color, and spectral Doppler ultrasonography examination of the internal jugular veins (IJVs), vertebral veins, and deep cerebral veins for stenosis, absence of signal, and reflux. Setting: Academic MS center. Patients: All patients with MS fulfilled revised McDonald criteria for the diagnosis of MS. Patients with clinically isolated syndrome exhibited a typical transient focal neurological deficit and had magnetic resonance imaging lesions typical of MS. Control subjects were recruited from the VA migraine clinic or staff. Main Outcome Measures: Five parameters of venous outflow used by Zamboni et al. were examined: (1) IJV or vertebral vein reflux, (2) deep cerebral vein reflux, (3) IJV stenosis, (4) absence of flow in IJVs or vertebral veins, and (5) change in cross-sectional area of the IJV with postural change. Results: There was no significant difference in the number and type of venous outflow abnormalities in patients with MS compared with controls. Conclusion: This study does not support the theory that chronic cerebral venous insufficiency exists in MS.
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U2 - 10.1001/archneurol.2011.185
DO - 10.1001/archneurol.2011.185
M3 - Article
C2 - 21825217
AN - SCOPUS:83455236113
SN - 0003-9942
VL - 68
SP - 1521
EP - 1525
JO - Archives of neurology
JF - Archives of neurology
IS - 12
ER -