No evidence that G6PD deficiency affects the efficacy or safety of daunorubicin in acute lymphoblastic leukemia induction therapy

Katherine M. Robinson, Wenjian Yang, Seth E. Karol, Nancy Kornegay, Dennis Jay, Cheng Cheng, John K. Choi, Dario Campana, Ching Hon Pui, Brent Wood, Michael J. Borowitz, Julie Gastier-Foster, Eric C. Larsen, Naomi J Winick, William L. Carroll, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Meenakshi Devidas, Elaine R. MardisRobert S. Fulton, Mary V. Relling, Sima Jeha

Research output: Contribution to journalArticle

Abstract

Background/Objectives: Anthracyclines are used in induction therapy of pediatric acute lymphoblastic leukemia (ALL) and are known to generate oxidative stress; whether this translates into enhanced antileukemic activity or hemolytic effects in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency is unknown. Design/Methods: Among 726 pediatric patients with newly diagnosed ALL treated at St. Jude Children's Research Hospital, 22 had deficient G6PD activity. We compared the prevalence of positive minimal residual disease (MRD) ≥1% at Day 15/Day 19 of induction or ≥0.01% at Day 42/Day 46 (end of induction) and the number of red blood cell (RBC) transfusions after daunorubicin in induction between patients with or without G6PD deficiency, adjusting for ALL risk group, treatment protocol, age, and gender. Results: There was no difference in Day 15/19 (P = 1) or end of induction MRD (P = 0.76) nor in the number of RBC transfusions (P = 0.73); the lack of association with MRD was confirmed in a dataset of 1192 newly diagnosed male patients enrolled in a Children's Oncology Group trial (P = 0.78). Conclusion: We found no evidence that G6PD deficiency affects daunorubicin activity during induction treatment for ALL.

Original languageEnglish (US)
Article numbere27681
JournalPediatric Blood and Cancer
DOIs
StatePublished - Jan 1 2019

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Keywords

  • daunorubicin
  • doxorubicin
  • glucose-6-phospate dehydrogenase
  • leukemia
  • pharmacogenetics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Robinson, K. M., Yang, W., Karol, S. E., Kornegay, N., Jay, D., Cheng, C., Choi, J. K., Campana, D., Pui, C. H., Wood, B., Borowitz, M. J., Gastier-Foster, J., Larsen, E. C., Winick, N. J., Carroll, W. L., Loh, M. L., Raetz, E. A., Hunger, S. P., Devidas, M., ... Jeha, S. (2019). No evidence that G6PD deficiency affects the efficacy or safety of daunorubicin in acute lymphoblastic leukemia induction therapy. Pediatric Blood and Cancer, [e27681]. https://doi.org/10.1002/pbc.27681