Nocturnin: A circadian target of Pparg-induced adipogenesis

Masanobu Kawai, Carla B. Green, Mark Horowitz, Cheryl Ackert-Bicknell, Beata Lecka-Czernik, Clifford J. Rosen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Scopus citations

Abstract

Nuclear receptors (NRs) control cell fate and regulate tissue function. Some of the NRs are expressed in a circadian and tissue-specific manner. Clock genes are part of the circadian network and fine-tune gene expression in adipose and skeletal tissues. Pparg, a master transcription factor that determines adipogenesis, exhibits a circadian expression pattern in white adipose tissue and liver. Here we report the finding that the message and protein for a peripheral clock gene, nocturnin, is markedly upregulated with Pparg activation in adipocytes and bone marrow stromal cells. Nocturnin is also expressed in relatively high amounts in other tissues that may have physiologic relevance for bone, including the brain and hypothalamus. Of importance, we found polymorphic strain differences in bone marrow nocturnin expression that relate to phenotypic determinants of skeletal acquisition. Defining the function of nocturnin in peripheral tissues should provide new insights into lineage allocation and the intimate relationship between nuclear receptors and physiologic timekeeping.

Original languageEnglish (US)
Title of host publicationSkeletal Biology and Medicine
PublisherBlackwell Publishing Inc.
Pages131-138
Number of pages8
ISBN (Print)9781573317856
DOIs
StatePublished - Mar 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1192
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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Keywords

  • Nocturnin
  • Nuclear receptor
  • Pparg

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Kawai, M., Green, C. B., Horowitz, M., Ackert-Bicknell, C., Lecka-Czernik, B., & Rosen, C. J. (2010). Nocturnin: A circadian target of Pparg-induced adipogenesis. In Skeletal Biology and Medicine (pp. 131-138). (Annals of the New York Academy of Sciences; Vol. 1192). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.05221.x