TY - GEN
T1 - Nocturnin
T2 - A circadian target of Pparg-induced adipogenesis
AU - Kawai, Masanobu
AU - Green, Carla B.
AU - Horowitz, Mark
AU - Ackert-Bicknell, Cheryl
AU - Lecka-Czernik, Beata
AU - Rosen, Clifford J.
PY - 2010/3
Y1 - 2010/3
N2 - Nuclear receptors (NRs) control cell fate and regulate tissue function. Some of the NRs are expressed in a circadian and tissue-specific manner. Clock genes are part of the circadian network and fine-tune gene expression in adipose and skeletal tissues. Pparg, a master transcription factor that determines adipogenesis, exhibits a circadian expression pattern in white adipose tissue and liver. Here we report the finding that the message and protein for a peripheral clock gene, nocturnin, is markedly upregulated with Pparg activation in adipocytes and bone marrow stromal cells. Nocturnin is also expressed in relatively high amounts in other tissues that may have physiologic relevance for bone, including the brain and hypothalamus. Of importance, we found polymorphic strain differences in bone marrow nocturnin expression that relate to phenotypic determinants of skeletal acquisition. Defining the function of nocturnin in peripheral tissues should provide new insights into lineage allocation and the intimate relationship between nuclear receptors and physiologic timekeeping.
AB - Nuclear receptors (NRs) control cell fate and regulate tissue function. Some of the NRs are expressed in a circadian and tissue-specific manner. Clock genes are part of the circadian network and fine-tune gene expression in adipose and skeletal tissues. Pparg, a master transcription factor that determines adipogenesis, exhibits a circadian expression pattern in white adipose tissue and liver. Here we report the finding that the message and protein for a peripheral clock gene, nocturnin, is markedly upregulated with Pparg activation in adipocytes and bone marrow stromal cells. Nocturnin is also expressed in relatively high amounts in other tissues that may have physiologic relevance for bone, including the brain and hypothalamus. Of importance, we found polymorphic strain differences in bone marrow nocturnin expression that relate to phenotypic determinants of skeletal acquisition. Defining the function of nocturnin in peripheral tissues should provide new insights into lineage allocation and the intimate relationship between nuclear receptors and physiologic timekeeping.
KW - Nocturnin
KW - Nuclear receptor
KW - Pparg
UR - http://www.scopus.com/inward/record.url?scp=77950669588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950669588&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05221.x
DO - 10.1111/j.1749-6632.2009.05221.x
M3 - Conference contribution
C2 - 20392228
AN - SCOPUS:77950669588
SN - 9781573317856
T3 - Annals of the New York Academy of Sciences
SP - 131
EP - 138
BT - Skeletal Biology and Medicine
PB - Blackwell Publishing Inc.
ER -