Nocturnin: At the crossroads of clocks and metabolism

Jeremy J. Stubblefield, Jérémy Terrien, Carla B. Green

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Many aspects of metabolism exhibit daily rhythmicity under the control of endogenous circadian clocks, and disruptions in circadian timing result in dysfunctions associated with the metabolic syndrome. Nocturnin (Noc) is a robustly rhythmic gene that encodes a deadenylase thought to be involved in the removal of polyA tails from mRNAs. Mice lacking the Noc gene display resistance to diet-induced obesity and hepatic steatosis, due in part to reduced lipid trafficking in the small intestine. In addition, Noc appears to play important roles in other tissues and has been implicated in lipid metabolism, adipogenesis, glucose homeostasis, inflammation and osteogenesis. Therefore, Noc is a potential key post-transcriptional mediator in the circadian control of many metabolic processes.

Original languageEnglish (US)
Pages (from-to)326-333
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume23
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Adipogenesis
Circadian Clocks
Periodicity
Lipid Metabolism
Osteogenesis
Genes
Small Intestine
Tail
Homeostasis
Obesity
Diet
Inflammation
Lipids
Glucose
Messenger RNA
nocturnin
Liver

Keywords

  • Ccrn4l
  • Circadian
  • Deadenylase
  • Metabolic syndrome
  • Nocturnin
  • Post-transcriptional

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Nocturnin : At the crossroads of clocks and metabolism. / Stubblefield, Jeremy J.; Terrien, Jérémy; Green, Carla B.

In: Trends in Endocrinology and Metabolism, Vol. 23, No. 7, 07.2012, p. 326-333.

Research output: Contribution to journalArticle

Stubblefield, Jeremy J. ; Terrien, Jérémy ; Green, Carla B. / Nocturnin : At the crossroads of clocks and metabolism. In: Trends in Endocrinology and Metabolism. 2012 ; Vol. 23, No. 7. pp. 326-333.
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