Nodular lesions of erythema elevatum diutinum in patients infected with the human immunodeficiency virus

P. E. LeBoit, C. J. Cockerell

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52 Scopus citations

Abstract

Background: Erythema elevatum diutinum (EED) is a rare, chronic form of cutaneous vasculitis that can result in fibrosis. Four patients infected with the human immunodeficiency virus (HIV) had unusual nodular lesions of EED. Objective: Our purpose was to document the occurrence of these lesions in HIV-infected patients and to characterize the histopathologic and immunophenotypic features of nodular EED. Methods: Clinicopathologic studies were supplemented by special stains of biopsy specimens. Results: EED may be a complication of HIV infection. Nodules of EED are composed of small aggregates of Mac-387+ spindled cells. Within the aggregates can be seen neutrophils, nuclear dust, and fibrin. The marked fibrosis of the lesions may account for the lack of response to dapsone. Conclusion: EED should be considered in the differential diagnosis of juxtaarticular nodules in HIV-infected patients; its diagnosis can be confirmed by biopsy.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume28
Issue number6
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Dermatology

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