TY - JOUR
T1 - Non-alcoholic fatty liver disease in the metabolic syndrome
AU - Palasciano, Guiseppe
AU - Moschetta, Antonio
AU - Palmieri, Vincenzo O.
AU - Grattagliano, Ignazio
AU - Iacobellis, Gianluca
AU - Portincasa, Piero
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/7
Y1 - 2007/7
N2 - Non-alcoholic fatty liver disease (NAFLD) is often associated with features of the metabolic syndrome, carrying an increased risk to develop non-alcoholic steatohepatitis (NASH), the inflammatory form of liver steatosis. Epidemiological data confirm that obesity, diabetes, hypertension and hyperlipidemia are frequently found in NAFLD and worsen its prognosis because of increased risk of fibrotic evolution, eventually leading to liver cirrhosis. Recent studies confirm the close relationship between the metabolic syndrome and liver steatosis, and further support the detrimental role of oxidative stress and lipid peroxidation, which are pathophysiological processes present in both conditions. Novel diagnostic tools and life style modifications together with targeted therapeutic actions are urgently needed for the management of liver dysfunction in course of metabolic syndrome.
AB - Non-alcoholic fatty liver disease (NAFLD) is often associated with features of the metabolic syndrome, carrying an increased risk to develop non-alcoholic steatohepatitis (NASH), the inflammatory form of liver steatosis. Epidemiological data confirm that obesity, diabetes, hypertension and hyperlipidemia are frequently found in NAFLD and worsen its prognosis because of increased risk of fibrotic evolution, eventually leading to liver cirrhosis. Recent studies confirm the close relationship between the metabolic syndrome and liver steatosis, and further support the detrimental role of oxidative stress and lipid peroxidation, which are pathophysiological processes present in both conditions. Novel diagnostic tools and life style modifications together with targeted therapeutic actions are urgently needed for the management of liver dysfunction in course of metabolic syndrome.
KW - Breath test
KW - Metabolic syndrome
KW - Non-alcoholic fatty liver disease
KW - Non-alcoholic steatohepatitis
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U2 - 10.2174/138161207781039652
DO - 10.2174/138161207781039652
M3 - Review article
C2 - 17627552
AN - SCOPUS:34447529333
SN - 1381-6128
VL - 13
SP - 2193
EP - 2198
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 21
ER -