Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development

Benjamin P. Weaver, Yi M. Weaver, Shizue Omi, Wang Yuan, Jonathan J. Ewbank, Min Han

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Weaver et al. describe a non-apoptotic role for CED-3 caspase during development in C. elegans. They show that a p38 MAPK pathway primes animals for stressful encounters by upregulating stress-responsive genes and slowing development. CED-3 antagonizes this stress response via proteolytic inactivation of p38, thus promoting development.

Original languageEnglish (US)
Pages (from-to)358-369.e6
JournalDevelopmental cell
Volume53
Issue number3
DOIs
StatePublished - May 4 2020

Keywords

  • DUSP
  • NLP-29
  • VHP-1
  • innate immunity
  • kinase
  • metabolism
  • non-apoptotic
  • phosphatase
  • proteostasis
  • translation

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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