@article{0fa40f9ab7634a58a3d27e6c38e6e63d,
title = "Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development",
abstract = "Weaver et al. describe a non-apoptotic role for CED-3 caspase during development in C. elegans. They show that a p38 MAPK pathway primes animals for stressful encounters by upregulating stress-responsive genes and slowing development. CED-3 antagonizes this stress response via proteolytic inactivation of p38, thus promoting development.",
keywords = "DUSP, NLP-29, VHP-1, innate immunity, kinase, metabolism, non-apoptotic, phosphatase, proteostasis, translation",
author = "Weaver, {Benjamin P.} and Weaver, {Yi M.} and Shizue Omi and Wang Yuan and Ewbank, {Jonathan J.} and Min Han",
note = "Funding Information: We thank D. Xue and the CGC (funded by NIH Office of Research Infrastructure Programs [ P40 OD010440 ]) for materials; D. Xue, W. Wood, A. Sewell, N. Pujol, M. Cobb, Han lab members, and Weaver lab members for helpful discussions; WormBase and OMIM databases for accessible information; and J. Belougne for worm sorting at the French National Functional Genomics platform, supported by the GIS IBiSA and Labex INFORM. The authors wish to thank T. Lee with the Central Analytical and Mass Spectrometry Laboratory at the University of Colorado Boulder for sample preparation and LC-MS/MS analysis of the samples with equipment purchased using funding from a W.M. Keck Foundation grant. The authors also wish to thank A. Scott and K. Hammond with the University of Colorado BioFrontiers Institute Next-Gen Sequencing Core Facility, which performed the Illumina sequencing. This work is supported in part by a Welch Foundation grant I-2022-20190330 (B.P.W.), National Institutes of Health grant R35GM133755-01 (B.P.W.), National Institutes of Health grant 5R01GM047869 (M.H.), the Howard Hughes Medical Institute (M.H.), the CNRS , INSERM , AMU , and the ANR ( ANR-16-CE15-0001-01 , ANR-11-LABX-0054 , and ANR-11-IDEX-0001-02 to J.J.E.). B.P.W. is the Virginia Murchison Linthicum Scholar in Medical Research at UT Southwestern Medical Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ",
year = "2020",
month = may,
day = "4",
doi = "10.1016/j.devcel.2020.03.015",
language = "English (US)",
volume = "53",
pages = "358--369.e6",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "3",
}