TY - JOUR
T1 - Non-coding RNAs as drug targets
AU - Matsui, Masayuki
AU - Corey, David R.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Most of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) may affect normal gene expression and disease progression, making them a new class of targets for drug discovery. Because their mechanisms of action are often novel, developing drugs to target ncRNAs will involve equally novel challenges. However, many potential problems may already have been solved during the development of technologies to target mRNA. Here, we discuss the growing field of ncRNA-including microRNA, intronic RNA, repetitive RNA and long non-coding RNA-and assess the potential and challenges in their therapeutic exploitation.
AB - Most of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) may affect normal gene expression and disease progression, making them a new class of targets for drug discovery. Because their mechanisms of action are often novel, developing drugs to target ncRNAs will involve equally novel challenges. However, many potential problems may already have been solved during the development of technologies to target mRNA. Here, we discuss the growing field of ncRNA-including microRNA, intronic RNA, repetitive RNA and long non-coding RNA-and assess the potential and challenges in their therapeutic exploitation.
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U2 - 10.1038/nrd.2016.117
DO - 10.1038/nrd.2016.117
M3 - Review article
C2 - 27444227
AN - SCOPUS:84979222074
SN - 1474-1776
VL - 16
SP - 167
EP - 179
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 3
ER -