Non-contrast-enhanced pulmonary vein MRI with a spatially selective slab inversion preparation sequence

Peng Hu, Michael L. Chuang, Kraig V. Kissinger, Beth Goddu, Lois A. Goepfert, Neil M. Rofsky, Warren J. Manning, Reza Nezafat

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We propose a non-contrast-enhanced, three-dimensional, freebreathing, electrocardiogram-gated, gradient recalled echo sequence with a slab-selective inversion for pulmonary vein (PV) MRI. A sagittal inversion slab was applied prior to data acquisition to suppress structures adjacent to the left atrium (LA) and PVs, thereby improving the conspicuity of the PV and LA. Compared with other MR angiography methods using an inversion pulse, the proposed method does not require signal subtraction and the inversion slab is not parallel to the imaging slab. The feasibility of the proposed method was demonstrated in healthy subjects. The inversion slab thickness and inversion time were optimized to be 60 mm and 500 ms, respectively. Compared to conventional gradient recalled echo imaging without inversion, the proposed technique significantly increased the contrast-to-noise ratios between the LA and the right atrium by 20-fold (P < 0.01), increased the contrast-tonoise ratios between the PVs and right atrium by 10-fold (P < 0.03), and increased the contrast-to-noise ratios between the PVs, LA and pulmonary artery by 4-fold (P < 0.01 for both). The signal-to-noise ratios of the PVs and the LA were similar with and without the inversion slab (P > 0.3). The proposed technique greatly enhances the conspicuity of the PVs and LA without significant loss of signal-to-noise ratio.

Original languageEnglish (US)
Pages (from-to)530-536
Number of pages7
JournalMagnetic Resonance in Medicine
Volume63
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Sequence Inversion
Pulmonary Veins
Heart Atria
Signal-To-Noise Ratio
Noise
Healthy Volunteers
Angiography
Electrocardiography

Keywords

  • Arterial spin labeling
  • Atrial fibrillation
  • Inversion
  • Non-contrast-enhanced MRA
  • Pulmonary vein angiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Non-contrast-enhanced pulmonary vein MRI with a spatially selective slab inversion preparation sequence. / Hu, Peng; Chuang, Michael L.; Kissinger, Kraig V.; Goddu, Beth; Goepfert, Lois A.; Rofsky, Neil M.; Manning, Warren J.; Nezafat, Reza.

In: Magnetic Resonance in Medicine, Vol. 63, No. 2, 02.2010, p. 530-536.

Research output: Contribution to journalArticle

Hu, P, Chuang, ML, Kissinger, KV, Goddu, B, Goepfert, LA, Rofsky, NM, Manning, WJ & Nezafat, R 2010, 'Non-contrast-enhanced pulmonary vein MRI with a spatially selective slab inversion preparation sequence', Magnetic Resonance in Medicine, vol. 63, no. 2, pp. 530-536. https://doi.org/10.1002/mrm.22252
Hu, Peng ; Chuang, Michael L. ; Kissinger, Kraig V. ; Goddu, Beth ; Goepfert, Lois A. ; Rofsky, Neil M. ; Manning, Warren J. ; Nezafat, Reza. / Non-contrast-enhanced pulmonary vein MRI with a spatially selective slab inversion preparation sequence. In: Magnetic Resonance in Medicine. 2010 ; Vol. 63, No. 2. pp. 530-536.
@article{a9baaa1961f44f6d8636ce66f6dc0cb4,
title = "Non-contrast-enhanced pulmonary vein MRI with a spatially selective slab inversion preparation sequence",
abstract = "We propose a non-contrast-enhanced, three-dimensional, freebreathing, electrocardiogram-gated, gradient recalled echo sequence with a slab-selective inversion for pulmonary vein (PV) MRI. A sagittal inversion slab was applied prior to data acquisition to suppress structures adjacent to the left atrium (LA) and PVs, thereby improving the conspicuity of the PV and LA. Compared with other MR angiography methods using an inversion pulse, the proposed method does not require signal subtraction and the inversion slab is not parallel to the imaging slab. The feasibility of the proposed method was demonstrated in healthy subjects. The inversion slab thickness and inversion time were optimized to be 60 mm and 500 ms, respectively. Compared to conventional gradient recalled echo imaging without inversion, the proposed technique significantly increased the contrast-to-noise ratios between the LA and the right atrium by 20-fold (P < 0.01), increased the contrast-tonoise ratios between the PVs and right atrium by 10-fold (P < 0.03), and increased the contrast-to-noise ratios between the PVs, LA and pulmonary artery by 4-fold (P < 0.01 for both). The signal-to-noise ratios of the PVs and the LA were similar with and without the inversion slab (P > 0.3). The proposed technique greatly enhances the conspicuity of the PVs and LA without significant loss of signal-to-noise ratio.",
keywords = "Arterial spin labeling, Atrial fibrillation, Inversion, Non-contrast-enhanced MRA, Pulmonary vein angiography",
author = "Peng Hu and Chuang, {Michael L.} and Kissinger, {Kraig V.} and Beth Goddu and Goepfert, {Lois A.} and Rofsky, {Neil M.} and Manning, {Warren J.} and Reza Nezafat",
year = "2010",
month = "2",
doi = "10.1002/mrm.22252",
language = "English (US)",
volume = "63",
pages = "530--536",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Non-contrast-enhanced pulmonary vein MRI with a spatially selective slab inversion preparation sequence

AU - Hu, Peng

AU - Chuang, Michael L.

AU - Kissinger, Kraig V.

AU - Goddu, Beth

AU - Goepfert, Lois A.

AU - Rofsky, Neil M.

AU - Manning, Warren J.

AU - Nezafat, Reza

PY - 2010/2

Y1 - 2010/2

N2 - We propose a non-contrast-enhanced, three-dimensional, freebreathing, electrocardiogram-gated, gradient recalled echo sequence with a slab-selective inversion for pulmonary vein (PV) MRI. A sagittal inversion slab was applied prior to data acquisition to suppress structures adjacent to the left atrium (LA) and PVs, thereby improving the conspicuity of the PV and LA. Compared with other MR angiography methods using an inversion pulse, the proposed method does not require signal subtraction and the inversion slab is not parallel to the imaging slab. The feasibility of the proposed method was demonstrated in healthy subjects. The inversion slab thickness and inversion time were optimized to be 60 mm and 500 ms, respectively. Compared to conventional gradient recalled echo imaging without inversion, the proposed technique significantly increased the contrast-to-noise ratios between the LA and the right atrium by 20-fold (P < 0.01), increased the contrast-tonoise ratios between the PVs and right atrium by 10-fold (P < 0.03), and increased the contrast-to-noise ratios between the PVs, LA and pulmonary artery by 4-fold (P < 0.01 for both). The signal-to-noise ratios of the PVs and the LA were similar with and without the inversion slab (P > 0.3). The proposed technique greatly enhances the conspicuity of the PVs and LA without significant loss of signal-to-noise ratio.

AB - We propose a non-contrast-enhanced, three-dimensional, freebreathing, electrocardiogram-gated, gradient recalled echo sequence with a slab-selective inversion for pulmonary vein (PV) MRI. A sagittal inversion slab was applied prior to data acquisition to suppress structures adjacent to the left atrium (LA) and PVs, thereby improving the conspicuity of the PV and LA. Compared with other MR angiography methods using an inversion pulse, the proposed method does not require signal subtraction and the inversion slab is not parallel to the imaging slab. The feasibility of the proposed method was demonstrated in healthy subjects. The inversion slab thickness and inversion time were optimized to be 60 mm and 500 ms, respectively. Compared to conventional gradient recalled echo imaging without inversion, the proposed technique significantly increased the contrast-to-noise ratios between the LA and the right atrium by 20-fold (P < 0.01), increased the contrast-tonoise ratios between the PVs and right atrium by 10-fold (P < 0.03), and increased the contrast-to-noise ratios between the PVs, LA and pulmonary artery by 4-fold (P < 0.01 for both). The signal-to-noise ratios of the PVs and the LA were similar with and without the inversion slab (P > 0.3). The proposed technique greatly enhances the conspicuity of the PVs and LA without significant loss of signal-to-noise ratio.

KW - Arterial spin labeling

KW - Atrial fibrillation

KW - Inversion

KW - Non-contrast-enhanced MRA

KW - Pulmonary vein angiography

UR - http://www.scopus.com/inward/record.url?scp=75749134505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749134505&partnerID=8YFLogxK

U2 - 10.1002/mrm.22252

DO - 10.1002/mrm.22252

M3 - Article

VL - 63

SP - 530

EP - 536

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -