Non-Histone Chromosomal Proteins of Chemically Transformed Neoplastic Cells in Tissue Culture

J. M. Forger, D. D. Choie, E. C. Friedberg

Research output: Contribution to journalArticle

17 Scopus citations


Chromatin proteins from control and dimethylnitrosamine-transformed baby hamster kidney cells were compared by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Our results indicate that non-histone chromosomal proteins from transformed cells contained protein components of low and intermediate electrophoretic mobility, which were deficient in normal cells. Comparison of the relative amount of incorporation of labeled amino acids into non-histone chromosomal proteins showed that protein components with a molecular weight of about 60,000 M.W. had a markedly increased labeling activity in the chemically transformed cells. These results suggest that changes in non-histone chromosomal proteins are associated with neoplastic transformation by chemical carcinogens.

Original languageEnglish (US)
Pages (from-to)258-262
Number of pages5
JournalCancer research
Issue number1
StatePublished - Jan 1 1976


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this