Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)

Amy G. Zhou, Justin A. Bishop, Syed Z. Ali

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a new term replacing what was previously known as non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC). These tumors show benign/indolent clinical behavior when compared with invasive FVPTC, which led to their reclassification as a “non-malignant” neoplasm. NIFTP shares essentially similar cytomorphologic features as FVPTC, and can only be definitively diagnosed on surgical excision specimens. This article provides an update on morphologic characteristics of NIFTP, along with pertinent molecular studies and management algorithms.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalJournal of the American Society of Cytopathology
Volume6
Issue number5
DOIs
StatePublished - Sep 1 2017

Keywords

  • Afirma gene expression classifier
  • Follicular variant of papillary thyroid carcinoma (FVPTC)
  • Indeterminate thyroid nodules
  • Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
  • Papillary thyroid carcinoma (PTC)
  • Thyroid fine needle aspiration (FNA)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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