Non-invasive physiology: 19F nmr of perfluorocarbons

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43 Scopus citations

Abstract

Ever since it was shown that the 19F NMR spin-lattice relaxation rates (Ri) of perfluorocarbon (PFC) emulsions are highly sensitive to oxygen tension (p02), there has been a developing interest in the use of PFCs to probe tissue physiology. Oxygen is required for efficient function by most tissues and hypoxia leads to rapid cellular dysfunction and damage. In addition, hypoxic tumor cells are refractory to radiotherapy. Thus, the opportunity to measure tissue oxygen tension noninvasively may be significant in understanding mechanisms of tissue function and in clinical prognosis. PFC NMR parameters are also sensitive to temperature, facilitating NMR thermometry with potential applications in hyperthermia studies. I will review the development of experimental techniques, applications to specific tissues and discuss the challenges and opportunities presented by 19F NMR of perfluorocarbons.

Original languageEnglish (US)
Pages (from-to)1141-1153
Number of pages13
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Volume22
Issue number4
DOIs
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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