TY - JOUR
T1 - Non-invasive physiology
T2 - 19F nmr of perfluorocarbons
AU - Mason, R. P.
N1 - Funding Information:
ACKNOWLEDGEMENTS I am grateful to the American Heart Association (Texas Affiliate) and Alliance Pharmaceutical Corp. for support and my colleagues for valuable discussions.
PY - 1994/1
Y1 - 1994/1
N2 - Ever since it was shown that the 19F NMR spin-lattice relaxation rates (Ri) of perfluorocarbon (PFC) emulsions are highly sensitive to oxygen tension (p02), there has been a developing interest in the use of PFCs to probe tissue physiology. Oxygen is required for efficient function by most tissues and hypoxia leads to rapid cellular dysfunction and damage. In addition, hypoxic tumor cells are refractory to radiotherapy. Thus, the opportunity to measure tissue oxygen tension noninvasively may be significant in understanding mechanisms of tissue function and in clinical prognosis. PFC NMR parameters are also sensitive to temperature, facilitating NMR thermometry with potential applications in hyperthermia studies. I will review the development of experimental techniques, applications to specific tissues and discuss the challenges and opportunities presented by 19F NMR of perfluorocarbons.
AB - Ever since it was shown that the 19F NMR spin-lattice relaxation rates (Ri) of perfluorocarbon (PFC) emulsions are highly sensitive to oxygen tension (p02), there has been a developing interest in the use of PFCs to probe tissue physiology. Oxygen is required for efficient function by most tissues and hypoxia leads to rapid cellular dysfunction and damage. In addition, hypoxic tumor cells are refractory to radiotherapy. Thus, the opportunity to measure tissue oxygen tension noninvasively may be significant in understanding mechanisms of tissue function and in clinical prognosis. PFC NMR parameters are also sensitive to temperature, facilitating NMR thermometry with potential applications in hyperthermia studies. I will review the development of experimental techniques, applications to specific tissues and discuss the challenges and opportunities presented by 19F NMR of perfluorocarbons.
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U2 - 10.3109/10731199409138809
DO - 10.3109/10731199409138809
M3 - Article
C2 - 7849916
AN - SCOPUS:0028021254
SN - 1073-1199
VL - 22
SP - 1141
EP - 1153
JO - Artificial Cells, Blood Substitutes, and Biotechnology
JF - Artificial Cells, Blood Substitutes, and Biotechnology
IS - 4
ER -