Non-invasive physiology: 19F NMR of perfluorocarbons

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Ever since it was shown that the 19F NMR spin-lattice relaxation rates (R1) of perfluorocarbon (PFC) emulsions are highly sensitive to oxygen tension (pO2), there has been a developing interest in the use of PFCs to probe tissue physiology. Oxygen is required for efficient function by most tissues and hypoxia leads to rapid cellular dysfunction and damage. In addition, hypoxic tumor cells are refractory to radiotherapy. Thus, the opportunity to measure tissue oxygen tension non-invasively may be significant in understanding mechanisms of tissue function and in clinical prognosis. PFC NMR parameters are also sensitive to temperature, facilitating NMR thermometry with potential applications in hyperthermia studies. I will review the development of experimental techniques, applications to specific tissues and discuss the challenges and opportunities presented by 19F NMR of perfluorocarbons.

Original languageEnglish (US)
Pages (from-to)1141-1153
Number of pages13
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number4
StatePublished - 1994

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Fluorocarbons
Physiology
Nuclear magnetic resonance
Tissue
Oxygen
Thermometry
Spin-lattice relaxation
Radiotherapy
Emulsions
Refractory materials
Tumors
Fever
Cells
Temperature
Neoplasms

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Non-invasive physiology : 19F NMR of perfluorocarbons. / Mason, R. P.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 4, 1994, p. 1141-1153.

Research output: Contribution to journalArticle

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