TY - JOUR
T1 - Non-motor symptoms in essential tremor
T2 - A review of the current data and state of the field
AU - Louis, Elan D.
N1 - Funding Information:
Dr. Louis has received research support from the National Institutes of Health : NINDS # R01 NS042859 (principal investigator), NINDS # R01 NS39422 (principal investigator), NINDS # R01 NS086736 (principal investigator), NINDS # R01 NS073872 (principal investigator), NINDS # R01 NS085136 (principal investigator) and NINDS # R01 NS088257 (principal investigator). This funding body played no role in the design of the study, the collection, analysis, and interpretation of data, or the writing of the manuscript.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/1
Y1 - 2016/1
N2 - Background: The motor features of essential tremor (ET) include its hallmark element, kinetic tremor, yet non-motor features are increasingly being recognized as an accompanying part of what was previously viewed as a solely motor disorder. Given the evolving state of the ET field with respect to these non-motor features, the purpose of this manuscript is to critically review the current data. Methods: A PubMed search was conducted on July 1, 2015. The term "essential tremor" was crossed in sequential order with 13 additional search terms (e.g., "cognitive", "dementia", "depression"). The total number of unique hits was 322. Results: Numerous studies seem to substantiate the presence of a range of non-motor features occurring in excess in ET cases compared to age-matched controls. These comprise cognitive features (including a full spectrum from mild cognitive difficulty through to frank dementia), psychiatric (including depression, apathy, anxiety, and personality characteristics), sensory (hearing and possibly olfactory abnormalities), and other non-motor features (e.g., sleep dysregulation). Emerging evidence suggests that some of these features could be primary disease features that pre-date motor features of ET. Conclusions: The presence of numerous non-motor features in ET is increasingly evident. The biological basis of these features deserves additional study.
AB - Background: The motor features of essential tremor (ET) include its hallmark element, kinetic tremor, yet non-motor features are increasingly being recognized as an accompanying part of what was previously viewed as a solely motor disorder. Given the evolving state of the ET field with respect to these non-motor features, the purpose of this manuscript is to critically review the current data. Methods: A PubMed search was conducted on July 1, 2015. The term "essential tremor" was crossed in sequential order with 13 additional search terms (e.g., "cognitive", "dementia", "depression"). The total number of unique hits was 322. Results: Numerous studies seem to substantiate the presence of a range of non-motor features occurring in excess in ET cases compared to age-matched controls. These comprise cognitive features (including a full spectrum from mild cognitive difficulty through to frank dementia), psychiatric (including depression, apathy, anxiety, and personality characteristics), sensory (hearing and possibly olfactory abnormalities), and other non-motor features (e.g., sleep dysregulation). Emerging evidence suggests that some of these features could be primary disease features that pre-date motor features of ET. Conclusions: The presence of numerous non-motor features in ET is increasingly evident. The biological basis of these features deserves additional study.
KW - Cognition
KW - Dementia
KW - Essential tremor
KW - Non-motor
KW - Psychiatric
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U2 - 10.1016/j.parkreldis.2015.08.034
DO - 10.1016/j.parkreldis.2015.08.034
M3 - Article
C2 - 26343494
AN - SCOPUS:84947870714
SN - 1353-8020
VL - 22
SP - S115-S118
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -