TY - JOUR
T1 - Non-nuclear estrogen receptor signaling in the endothelium
AU - Wu, Qian
AU - Chambliss, Ken
AU - Umetani, Michihisa
AU - Mineo, Chieko
AU - Shaul, Philip W.
PY - 2011/4/29
Y1 - 2011/4/29
N2 - In addition to the classical function of estrogen receptors (ER) as transcription factors, evidence continues to accumulate that they mediate non-nuclear processes in numerous cell types, including the endothelium, in which they activate endothelial NO synthase. Non-nuclear ER signaling entails unique posttranslational modifications and protein-protein interactions of the receptor with adaptor molecules, kinases, and G proteins. Recent in vitro and in vivo studies in mice using an estrogendendrimer conjugate that is excluded from the nucleus indicate that non-nuclear ER activation underlies the migration and growth responses of endothelial cells to estrogen but not the growth responses of endometrial or breast cancer cells to the hormone. In this minireview, the features of ERα and proteinprotein interactions that enable it to invoke extranuclear signaling in the endothelium and the consequences of that signaling are discussed.
AB - In addition to the classical function of estrogen receptors (ER) as transcription factors, evidence continues to accumulate that they mediate non-nuclear processes in numerous cell types, including the endothelium, in which they activate endothelial NO synthase. Non-nuclear ER signaling entails unique posttranslational modifications and protein-protein interactions of the receptor with adaptor molecules, kinases, and G proteins. Recent in vitro and in vivo studies in mice using an estrogendendrimer conjugate that is excluded from the nucleus indicate that non-nuclear ER activation underlies the migration and growth responses of endothelial cells to estrogen but not the growth responses of endometrial or breast cancer cells to the hormone. In this minireview, the features of ERα and proteinprotein interactions that enable it to invoke extranuclear signaling in the endothelium and the consequences of that signaling are discussed.
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U2 - 10.1074/jbc.R110.191791
DO - 10.1074/jbc.R110.191791
M3 - Review article
C2 - 21343284
AN - SCOPUS:79955445707
SN - 0021-9258
VL - 286
SP - 14737
EP - 14743
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 17
ER -