Non-shivering thermogenesis as a mechanism to facilitate sustainable weight loss

B. F. Palmer, D. J. Clegg

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Currently, there is a significant percentage of the population who are or will be classified as obese, necessitating novel strategies to facilitate sustainable weight loss. Reductions in basal metabolic rate occur in the face of weight loss and pose formidable barriers to individuals attempting to sustain meaningful weight reductions. Here, we discuss the mechanisms by which non-shivering thermogenesis may provide insight into metabolic pathways that can become druggable targets to facilitate sustainable weight loss. Specifically, we highlight the fact that non-shivering thermogenesis results in activation and expansion of brown and beige adipose tissues as well as activates pathways in skeletal muscle which increase metabolic flux and activity of muscle fibres through futile calcium cycling across the endoplasmic reticulum all facilitating an increase in metabolism. Finally, we highlight the fact there are sexual dimorphisms with respect to these metabolic processes in keeping with the National Institutes of Health mandate of treating sex as a biologic variable.

Original languageEnglish (US)
Pages (from-to)819-831
Number of pages13
JournalObesity Reviews
Volume18
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Thermogenesis
Weight Loss
Substrate Cycling
Basal Metabolism
Brown Adipose Tissue
National Institutes of Health (U.S.)
Metabolic Networks and Pathways
Sex Characteristics
Endoplasmic Reticulum
Skeletal Muscle
Calcium
Muscles
Population

Keywords

  • Brown/beige
  • estrogen
  • non-shivering thermogenesis
  • sexual dimorphism
  • weight loss

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Non-shivering thermogenesis as a mechanism to facilitate sustainable weight loss. / Palmer, B. F.; Clegg, D. J.

In: Obesity Reviews, Vol. 18, No. 8, 01.08.2017, p. 819-831.

Research output: Contribution to journalReview article

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