Non-small cell lung cancer and central nervous system metastases: Should we be using prophylactic cranial irradiation?

Elizabeth Gore, Hak Choy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Central nervous system (CNS) failure in patients with locally advanced non-small cell; lung cancer (LA-NSCLC) is a common and debilitating problem. Standard follow-up after local regional therapy does not include routine radiologic evaluation of the brain. Imaging is performed at the onset of symptoms followed by palliative therapy for CNS failure. Some investigators support regular screening with therapy for failures before the onset of symptoms. This alternative may decrease the impact of CNS failures and lengthen survival. Other investigators have shown that prophylactic cranial irradiation (PCI) for LA-NSCLC decreases the incidence of CNS failures. The potential survival, quality of life, and neuropsychological advantage or disadvantage of these two approaches has not been systematically studied. This article will review the problem of CNS failures in patients with LA-NSCLC and the potential risks and benefits of close observation and PCI. The necessity of conducting an ambitious study evaluating the potential survival advantage of PCI will be discussed.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalSeminars in Radiation Oncology
Volume14
Issue number4
DOIs
StatePublished - Oct 2004

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system failures
Cranial Irradiation
central nervous system
metastasis
Non-Small Cell Lung Carcinoma
lungs
Central Nervous System
cancer
Neoplasm Metastasis
irradiation
therapy
Survival
Research Personnel
Palliative Care
brain
Lung Neoplasms
screening
incidence
Quality of Life
Observation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

Non-small cell lung cancer and central nervous system metastases : Should we be using prophylactic cranial irradiation? / Gore, Elizabeth; Choy, Hak.

In: Seminars in Radiation Oncology, Vol. 14, No. 4, 10.2004, p. 292-297.

Research output: Contribution to journalArticle

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