Non-squamous variants of human papillomavirus-related head and neck carcinoma

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Human papillomavirus (HPV) is now well established as an important causative agent in a subset of head and neck cancers. HPV-related head and neck carcinomas are important to recognize because these malignancies are associated with better survival and an improved response to therapy when compared to their HPV-negative counterparts. HPV-related head and neck cancer characteristically takes the form of a non-keratinizing squamous cell carcinoma. Widespread HPV testing of head and neck tumours, however, has revealed variants that depart from the standard HPV-related squamous cell carcinoma morphology. Most recently, examples of HPV-related carcinomas that actually lack a squamous phenotype, at least partially, have been reported. This manuscript will discuss these non-squamous variants of HPV-related head and neck carcinomas: adenosquamous carcinoma, adenocarcinoma, small cell carcinoma, sarcomatoid carcinoma, and sinonasal carcinoma with adenoid cystic-like features.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalDiagnostic Histopathology
Issue number8
StatePublished - 2014


  • Adenocarcinoma
  • Adenosquamous carcinoma
  • HPV
  • Human papillomavirus
  • Sarcomatoid carcinoma
  • Sinonasal carcinoma with adenoid cystic-like features
  • Small cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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