Non-surgical management of stress urinary incontinence: Ambulatory treatments for leakage associated with stress (ATLAS) trial

Holly E. Richter, Kathryn L. Burgio, Patricia S. Goode, Diane Borello-France, Catherine S. Bradley, Linda Brubaker, Victoria L. Handa, Paul M. Fine, Anthony G. Visco, Halina M. Zyczynski, John T. Wei, Anne M. Weber, Holly E. Richter, Kathryn L. Burgio, Patricia S. Goode, R. Edward Varner, Gregg Shore, Velria Willis, Paul M. Fine, Rodney A. AppellPeter K. Thompson, Peter M. Lotze, Naomi Frierson, Karl Kreder, Denise Haury, Debra Brandt, Catherine S. Bradley, Ingrid Nygaard, Satish Rao, Geoffrey Cundiff, Victoria Handa, Mary Elizabeth Sauter, Jamie Wright, Linda Brubaker, Mary Pat FitzGerald, Kimberly Kenton, Elizabeth Mueller, Kathy Marchese, Judith Senka, Kathleen Jesse, Morton B. Brown, John T. Wei, Beverly Marchant, John O.L. DeLancey, Nancy K. Janz, Patricia A. Wren, James Imus, Yang Wang Casher, Dee Fenner, Anthony G. Visco, Anna Marie Connolly, John Lavelle, Mary J. Lavelle, Anita K. Murphy, Ellen C. Wells, William Whitehead, Julia Fielding, Halina Zyczynski, Diane Borello-France, Christiane Hakim, Arnold Wald, Judy A. Gruss, Wendy Leng, Pamela A. Moalli, Robert Park

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background: Non-surgical treatment for stress urinary incontinence (SUI) is recommended as first-line therapy, yet few prospective studies and no randomized trials compare the most common non-surgical treatments for SUI. Purpose: To present the design and methodology of the ambulatory treatments for leakage associated with stress (ATLAS) trial, a randomized clinical trial comparing three interventions for predominant SUI in women: intravaginal continence pessary; behavioral therapy (including pelvic floor muscle training and exercise and bladder control strategies); and a combination of the two treatments. Methods: Treatment outcome measures, collected at 12 weeks and six and 12 months post randomization, include the Patient Global Impression of Improvement (PGI-I), the Stress Incontinence Scale of the Pelvic Floor Distress Inventory (PFDI), seven-day bladder diaries, Pelvic Floor Impact Questionnaire (PFIQ), Pelvic Organ Prolapse-Urinary Incontinence Sexual Function Questionnaire (PISQ-12), Patient Satisfaction Questionnaire (PSQ) and the Medical Outcomes Study Short Form Health Survey (SF-36). Limitations: The study design reduces most common biases, but some degree of selection bias may remain. Conclusion: This trial will provide useful information to help counsel women with stress and mixed incontinence about the relative efficacy and satisfaction with pessary, behavioral therapy and both treatments combined.

Original languageEnglish (US)
Pages (from-to)92-101
Number of pages10
JournalClinical Trials
Volume4
Issue number1
DOIs
Publication statusPublished - Dec 1 2007

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Richter, H. E., Burgio, K. L., Goode, P. S., Borello-France, D., Bradley, C. S., Brubaker, L., ... Park, R. (2007). Non-surgical management of stress urinary incontinence: Ambulatory treatments for leakage associated with stress (ATLAS) trial. Clinical Trials, 4(1), 92-101. https://doi.org/10.1177/1740774506075237