Nonblack patients with sickle cell disease have African β(s) gene cluster haplotypes

Z. R. Rogers, D. R. Powars, T. R. Kinney, W. D. Williams, W. A. Schroeder

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Abstract

Of 18 nonblack patients with sickle cell disease, 14 had sickel cell anemia, 2 had hemoglobin SC disease, and 2 had hemoglobin S-β(o)-thalassemia. The β(s) gene cluster haplotypes that were determined in 7 patients were of African origin and were identified as Central African Republic, Central African Republic minor II, Benin, and Senegal. The haplotype Central African Republic minor II was present on the β(o)-thalassemia chromosome in 2 patients. None of 10 patients whose α-gene status was determined had α-thalassemia-2. These data strongly support the concept that the β(s) gene on chromosome 11 of these individuals is of African origin and that the α-gene locus on chromosome 16 is of white or native American origin. The clinical severity of the disease in these nonblack patients is appropriate to their haplotype without α-thalassemia-2 and is comparable with that of black patients. All persons with congenital hemolytic anemia should be examined for the presence of sickel cell disease regardless of physical appearance or ethnic background.

Original languageEnglish (US)
Pages (from-to)2991-2994
Number of pages4
JournalJournal of the American Medical Association
Volume261
Issue number20
StatePublished - 1989

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Sickle Cell Anemia
Multigene Family
Haplotypes
Thalassemia
Central African Republic
Hemoglobin SC Disease
Congenital Hemolytic Anemia
Genes
Sickle Hemoglobin
Benin
Chromosomes, Human, Pair 16
Senegal
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
North American Indians
Anemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rogers, Z. R., Powars, D. R., Kinney, T. R., Williams, W. D., & Schroeder, W. A. (1989). Nonblack patients with sickle cell disease have African β(s) gene cluster haplotypes. Journal of the American Medical Association, 261(20), 2991-2994.

Nonblack patients with sickle cell disease have African β(s) gene cluster haplotypes. / Rogers, Z. R.; Powars, D. R.; Kinney, T. R.; Williams, W. D.; Schroeder, W. A.

In: Journal of the American Medical Association, Vol. 261, No. 20, 1989, p. 2991-2994.

Research output: Contribution to journalArticle

Rogers, ZR, Powars, DR, Kinney, TR, Williams, WD & Schroeder, WA 1989, 'Nonblack patients with sickle cell disease have African β(s) gene cluster haplotypes', Journal of the American Medical Association, vol. 261, no. 20, pp. 2991-2994.
Rogers, Z. R. ; Powars, D. R. ; Kinney, T. R. ; Williams, W. D. ; Schroeder, W. A. / Nonblack patients with sickle cell disease have African β(s) gene cluster haplotypes. In: Journal of the American Medical Association. 1989 ; Vol. 261, No. 20. pp. 2991-2994.
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