Noncanonical cell death pathways act during Drosophila oogenesis

Jeanne S. Peterson, B. Paige Bass, Deborah Jue, Antony Rodriguez, John M. Abrams, Kimberly McCall

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Programmed cell death (PCD) is a highly conserved process that occurs during development and in response to adverse conditions. In Drosophila, most PCDs require the genes within the H99 deficiency, the adaptor molecule Ark, and caspases. Here we investigate 10 cell death genes for their potential roles in two distinct types of PCD that occur in oogenesis: developmental nurse cell PCD and starvation-induced PCD. Most of the genes investigated were found to have little effect on late stage developmental PCD in oogenesis, although ark mutants showed a partial inhibition. Mid-stage starvation-induced germline PCD was found to be independent of the upstream activators and ark although it requires caspases, suggesting an apoptosome-independent mechanism of caspase activation in mid-oogenesis. These results indicate that novel pathways must control PCD in the ovary.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalGenesis
Volume45
Issue number6
DOIs
Publication statusPublished - Jun 2007

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Keywords

  • Apoptosis
  • Ark
  • debcl
  • Drosophila
  • Oogenesis
  • Programmed cell death
  • Sickle

ASJC Scopus subject areas

  • Genetics

Cite this

Peterson, J. S., Bass, B. P., Jue, D., Rodriguez, A., Abrams, J. M., & McCall, K. (2007). Noncanonical cell death pathways act during Drosophila oogenesis. Genesis, 45(6), 396-404. https://doi.org/10.1002/dvg.20306