Noncanonical cell death pathways act during Drosophila oogenesis

Jeanne S. Peterson, B. Paige Bass, Deborah Jue, Antony Rodriguez, John M. Abrams, Kimberly McCall

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Programmed cell death (PCD) is a highly conserved process that occurs during development and in response to adverse conditions. In Drosophila, most PCDs require the genes within the H99 deficiency, the adaptor molecule Ark, and caspases. Here we investigate 10 cell death genes for their potential roles in two distinct types of PCD that occur in oogenesis: developmental nurse cell PCD and starvation-induced PCD. Most of the genes investigated were found to have little effect on late stage developmental PCD in oogenesis, although ark mutants showed a partial inhibition. Mid-stage starvation-induced germline PCD was found to be independent of the upstream activators and ark although it requires caspases, suggesting an apoptosome-independent mechanism of caspase activation in mid-oogenesis. These results indicate that novel pathways must control PCD in the ovary.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalGenesis
Volume45
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint

Oogenesis
Drosophila
Cell Death
Caspases
Starvation
Apoptosomes
Genes
Ovary
Nurses

Keywords

  • Apoptosis
  • Ark
  • debcl
  • Drosophila
  • Oogenesis
  • Programmed cell death
  • Sickle

ASJC Scopus subject areas

  • Genetics

Cite this

Peterson, J. S., Bass, B. P., Jue, D., Rodriguez, A., Abrams, J. M., & McCall, K. (2007). Noncanonical cell death pathways act during Drosophila oogenesis. Genesis, 45(6), 396-404. https://doi.org/10.1002/dvg.20306

Noncanonical cell death pathways act during Drosophila oogenesis. / Peterson, Jeanne S.; Bass, B. Paige; Jue, Deborah; Rodriguez, Antony; Abrams, John M.; McCall, Kimberly.

In: Genesis, Vol. 45, No. 6, 06.2007, p. 396-404.

Research output: Contribution to journalArticle

Peterson, JS, Bass, BP, Jue, D, Rodriguez, A, Abrams, JM & McCall, K 2007, 'Noncanonical cell death pathways act during Drosophila oogenesis', Genesis, vol. 45, no. 6, pp. 396-404. https://doi.org/10.1002/dvg.20306
Peterson JS, Bass BP, Jue D, Rodriguez A, Abrams JM, McCall K. Noncanonical cell death pathways act during Drosophila oogenesis. Genesis. 2007 Jun;45(6):396-404. https://doi.org/10.1002/dvg.20306
Peterson, Jeanne S. ; Bass, B. Paige ; Jue, Deborah ; Rodriguez, Antony ; Abrams, John M. ; McCall, Kimberly. / Noncanonical cell death pathways act during Drosophila oogenesis. In: Genesis. 2007 ; Vol. 45, No. 6. pp. 396-404.
@article{43fcf4b95759411db39bb4a0f680b291,
title = "Noncanonical cell death pathways act during Drosophila oogenesis",
abstract = "Programmed cell death (PCD) is a highly conserved process that occurs during development and in response to adverse conditions. In Drosophila, most PCDs require the genes within the H99 deficiency, the adaptor molecule Ark, and caspases. Here we investigate 10 cell death genes for their potential roles in two distinct types of PCD that occur in oogenesis: developmental nurse cell PCD and starvation-induced PCD. Most of the genes investigated were found to have little effect on late stage developmental PCD in oogenesis, although ark mutants showed a partial inhibition. Mid-stage starvation-induced germline PCD was found to be independent of the upstream activators and ark although it requires caspases, suggesting an apoptosome-independent mechanism of caspase activation in mid-oogenesis. These results indicate that novel pathways must control PCD in the ovary.",
keywords = "Apoptosis, Ark, debcl, Drosophila, Oogenesis, Programmed cell death, Sickle",
author = "Peterson, {Jeanne S.} and Bass, {B. Paige} and Deborah Jue and Antony Rodriguez and Abrams, {John M.} and Kimberly McCall",
year = "2007",
month = "6",
doi = "10.1002/dvg.20306",
language = "English (US)",
volume = "45",
pages = "396--404",
journal = "Genesis",
issn = "1526-954X",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Noncanonical cell death pathways act during Drosophila oogenesis

AU - Peterson, Jeanne S.

AU - Bass, B. Paige

AU - Jue, Deborah

AU - Rodriguez, Antony

AU - Abrams, John M.

AU - McCall, Kimberly

PY - 2007/6

Y1 - 2007/6

N2 - Programmed cell death (PCD) is a highly conserved process that occurs during development and in response to adverse conditions. In Drosophila, most PCDs require the genes within the H99 deficiency, the adaptor molecule Ark, and caspases. Here we investigate 10 cell death genes for their potential roles in two distinct types of PCD that occur in oogenesis: developmental nurse cell PCD and starvation-induced PCD. Most of the genes investigated were found to have little effect on late stage developmental PCD in oogenesis, although ark mutants showed a partial inhibition. Mid-stage starvation-induced germline PCD was found to be independent of the upstream activators and ark although it requires caspases, suggesting an apoptosome-independent mechanism of caspase activation in mid-oogenesis. These results indicate that novel pathways must control PCD in the ovary.

AB - Programmed cell death (PCD) is a highly conserved process that occurs during development and in response to adverse conditions. In Drosophila, most PCDs require the genes within the H99 deficiency, the adaptor molecule Ark, and caspases. Here we investigate 10 cell death genes for their potential roles in two distinct types of PCD that occur in oogenesis: developmental nurse cell PCD and starvation-induced PCD. Most of the genes investigated were found to have little effect on late stage developmental PCD in oogenesis, although ark mutants showed a partial inhibition. Mid-stage starvation-induced germline PCD was found to be independent of the upstream activators and ark although it requires caspases, suggesting an apoptosome-independent mechanism of caspase activation in mid-oogenesis. These results indicate that novel pathways must control PCD in the ovary.

KW - Apoptosis

KW - Ark

KW - debcl

KW - Drosophila

KW - Oogenesis

KW - Programmed cell death

KW - Sickle

UR - http://www.scopus.com/inward/record.url?scp=34347360640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347360640&partnerID=8YFLogxK

U2 - 10.1002/dvg.20306

DO - 10.1002/dvg.20306

M3 - Article

C2 - 17506088

AN - SCOPUS:34347360640

VL - 45

SP - 396

EP - 404

JO - Genesis

JF - Genesis

SN - 1526-954X

IS - 6

ER -