Nonhomologous End Joining in Eukaryotes

E. Weterings, D. J. Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This article discusses the core mechanism of the nonhomologous end-joining (NHEJ) process: one of two pathways that mediate the repair of DNA double-strand breaks (DSBs) in eukaryotic cells. Through complex interplay of several enzymes, NHEJ facilitates the capture, tethering, processing, and ligation of the two ends of a broken DNA molecule. The individual roles of all key NHEJ enzymes are discussed, as well as the rare human disease patterns that can arise by impairment of these enzymes. In addition, a brief description is given of cellular processes, other than DSB repair, that also utilize the NHEJ machinery.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages269-274
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

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Keywords

  • Artemis
  • ATM
  • Cancer
  • Cernunnos
  • DNA double-strand break
  • DNA repair
  • DNA-PK
  • Ionizing radiation
  • Ku70/80
  • Ligase IV
  • NHEJ
  • Nonhomologous end joining
  • V(D)J recombination
  • XLF
  • XRCC4

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Weterings, E., & Chen, D. J. (2013). Nonhomologous End Joining in Eukaryotes. In Encyclopedia of Biological Chemistry: Second Edition (pp. 269-274). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00272-3