Noninvasive Doppler Tissue Measurement of Pulmonary Artery Compliance in Children with Pulmonary Hypertension

Karrie Dyer, Craig Lanning, Bibhuti Das, Po Feng Lee, D. Dunbar Ivy, Lilliam Valdes-Cruz, Robin Shandas

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background: We have shown previously that input impedance of the pulmonary vasculature provides a comprehensive characterization of right ventricular afterload by including compliance. However, impedance-based compliance assessment requires invasive measurements. Here, we develop and validate a noninvasive method to measure pulmonary artery (PA) compliance using ultrasound color M-mode (CMM) Doppler tissue imaging (DTI). Methods: Dynamic compliance (Cdyn) of the PA was obtained from CMM DTI and continuous wave Doppler measurement of the tricuspid regurgitant velocity. Cdyn was calculated as: [(Ds - Dd)/(Dd × Ps)] × 104; where Ds = systolic diameter, Dd = diastolic diameter, and Ps = systolic pressure. The method was validated both in vitro and in 13 patients in the catheterization laboratory, and then tested on 27 pediatric patients with pulmonary hypertension, with comparison with 10 age-matched control subjects. Cdyn was also measured in an additional 13 patients undergoing reactivity studies. Results: Instantaneous diameter measured using CMM DTI agreed well with intravascular ultrasound measurements in the in vitro models. Clinically, Cdyn calculated by CMM DTI agreed with Cdyn calculated using invasive techniques (23.4 ± 16.8 vs 29.1 ± 20.6%/100 mm Hg; P = not significant). Patients with pulmonary hypertension had significantly lower peak wall velocity values and lower Cdyn values than control subjects (P < .01). Cdyn values followed an exponentially decaying relationship with PA pressure, indicating the nonlinear stress-strain behavior of these arteries. Reactivity in Cdyn agreed with reactivity measured using impedance techniques. Conclusion: The Cdyn method provides a noninvasive means of assessing PA compliance and should be useful as an additional measure of vascular reactivity subsequent to pulmonary vascular resistance in patients with pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)403-412
Number of pages10
JournalJournal of the American Society of Echocardiography
Volume19
Issue number4
DOIs
StatePublished - Apr 2006

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Lung Compliance
Pulmonary Hypertension
Pulmonary Artery
Color
Electric Impedance
Compliance
Catheterization
Vascular Resistance
Blood Vessels
Arteries
Pediatrics
Blood Pressure
Pressure
Lung

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Noninvasive Doppler Tissue Measurement of Pulmonary Artery Compliance in Children with Pulmonary Hypertension. / Dyer, Karrie; Lanning, Craig; Das, Bibhuti; Lee, Po Feng; Ivy, D. Dunbar; Valdes-Cruz, Lilliam; Shandas, Robin.

In: Journal of the American Society of Echocardiography, Vol. 19, No. 4, 04.2006, p. 403-412.

Research output: Contribution to journalArticle

Dyer, Karrie ; Lanning, Craig ; Das, Bibhuti ; Lee, Po Feng ; Ivy, D. Dunbar ; Valdes-Cruz, Lilliam ; Shandas, Robin. / Noninvasive Doppler Tissue Measurement of Pulmonary Artery Compliance in Children with Pulmonary Hypertension. In: Journal of the American Society of Echocardiography. 2006 ; Vol. 19, No. 4. pp. 403-412.
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