Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes

Kwang Hyun Song, Chulhong Kim, Konstantin Maslov, Lihong V. Wang

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

Sentinel lymph node (SLN) biopsy has increasingly become important in axillary staging of breast cancer patients since SLN biopsy alleviates the postoperative complications of previously practiced axillary lymph node dissections. Nevertheless, the procedures of SLN biopsy using blue dye and radioactive substance are still intraoperative, and the latter methods are also ionizing. In this pilot study, we have proposed noninvasive in vivo spectroscopic photoacoustic (PA) SLN mapping using gold nanorods as lymph node tracers in a rat model. Gold nanorods have biocompatibility, high optical absorption, and easily tuned surface plasmon resonance peak wavelength.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalEuropean Journal of Radiology
Volume70
Issue number2
DOIs
StatePublished - May 2009

Keywords

  • Nanorods
  • Photoacoustic imaging
  • Sentinel lymph node biopsy
  • Spectroscopic

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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