Noninvasive investigation of blood oxygenation dynamics of tumors by near-infrared spectroscopy

Hanli Liu, Yulin Song, Katherine L. Worden, Xin Jiang, Anca Constantinescu, Ralph P. Mason

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

The measurement of dynamic changes in the blood oxygenation of tumor vasculature could be valuable for tumor prognosis and optimizing tumor treatment plans. In this study we employed near-infrared spectroscopy (NIRS) to measure changes in the total hemoglobin concentration together with the degree of hemoglobin oxygenation in the vascular bed of breast and prostate tumors implanted in rats. Measurements were made while inhaled gas was alternated between 33% oxygen and carbogen (95% O2, 5% CO2). Significant dynamic changes in tumor oxygenation were observed to accompany respiratory challenge, and these changes could be modeled with two exponential components, yielding two time constants. Following the Fick principle, we derived a simplified model to relate the time constants to tumor blood-perfusion rates. This study demonstrates that the NIRS technology can provide an efficient, real-time, noninvasive means of monitoring the vascular oxygenation dynamics of tumors and facilitate investigations of tumor vascular perfusion. This may have prognostic value and promises insight into tumor vascular development.

Original languageEnglish (US)
Pages (from-to)5231-5243
Number of pages13
JournalApplied Optics
Volume39
Issue number28
StatePublished - Oct 1 2000

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Near infrared spectroscopy
Oxygenation
oxygenation
blood
Tumors
Blood
tumors
infrared spectroscopy
Hemoglobin
hemoglobin
time constant
prognosis
breast
rats
Rats
beds
Oxygen
Monitoring

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Liu, H., Song, Y., Worden, K. L., Jiang, X., Constantinescu, A., & Mason, R. P. (2000). Noninvasive investigation of blood oxygenation dynamics of tumors by near-infrared spectroscopy. Applied Optics, 39(28), 5231-5243.

Noninvasive investigation of blood oxygenation dynamics of tumors by near-infrared spectroscopy. / Liu, Hanli; Song, Yulin; Worden, Katherine L.; Jiang, Xin; Constantinescu, Anca; Mason, Ralph P.

In: Applied Optics, Vol. 39, No. 28, 01.10.2000, p. 5231-5243.

Research output: Contribution to journalArticle

Liu, H, Song, Y, Worden, KL, Jiang, X, Constantinescu, A & Mason, RP 2000, 'Noninvasive investigation of blood oxygenation dynamics of tumors by near-infrared spectroscopy', Applied Optics, vol. 39, no. 28, pp. 5231-5243.
Liu H, Song Y, Worden KL, Jiang X, Constantinescu A, Mason RP. Noninvasive investigation of blood oxygenation dynamics of tumors by near-infrared spectroscopy. Applied Optics. 2000 Oct 1;39(28):5231-5243.
Liu, Hanli ; Song, Yulin ; Worden, Katherine L. ; Jiang, Xin ; Constantinescu, Anca ; Mason, Ralph P. / Noninvasive investigation of blood oxygenation dynamics of tumors by near-infrared spectroscopy. In: Applied Optics. 2000 ; Vol. 39, No. 28. pp. 5231-5243.
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