Noninvasive, medical management for non-ST-elevation acute coronary syndromes

Mark Y. Chan, Richard C. Becker, Robert A. Harrington, Eric D. Peterson, Paul W. Armstrong, Harvey White, Keith A.A. Fox, E. Magnus Ohman, Matthew T. Roe

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Despite emphasis on the use of invasive management strategies for patients with non-ST-elevation acute coronary syndromes (NSTE ACS) in recent practice guidelines, 27% to 56% of NSTE ACS patients do not undergo diagnostic angiography, and a further 45% to 78% do not undergo revascularization procedures during the initial hospitalization. These medically managed patients (also termed noninvasive management) have a greater frequency of medical comorbidities and high-risk clinical characteristics and are less likely to receive guideline-recommended medications, compared with patients who undergo revascularization procedures. The rates of short and long-term adverse outcomes are also substantially higher in medically managed NSTE ACS patients, but more widespread implementation of contemporary medical therapies in this population is limited by exclusion of medically managed patients from many randomized clinical trials.

Original languageEnglish (US)
Pages (from-to)397-407
Number of pages11
JournalAmerican heart journal
Issue number3
StatePublished - Mar 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Noninvasive, medical management for non-ST-elevation acute coronary syndromes'. Together they form a unique fingerprint.

Cite this