Noninvasive perfusion MRI in Alzheimer's disease

A preliminary report

T. A. Sandson, M. O'Connor, R. A. Sperling, R. R. Edelman, S. Warach

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We performed functional MRI using the echo-planar imaging and signal targeting with alternating radio frequency (EPISTAR) technique in 11 patients with Alzheimer's disease (AD) and 8 age-matched control subjects. Seven of the AD patients had qualitatively apparent focal areas of hypoperfusion in the posterior temporoparietal-occipital regions. At the earliest inversion time producing cortical enhancement, the ratios of parietooccipital and temporo-occipital to whole slice signal intensity were significantly lower in the AD patients than in the controls. Parieto-occipital hypoperfusion correlated with dementia severity as measured by the Blessed Dementia Scale. EPISTAR may prove to be a rapid, noninvasive alternative to other functional neuroimaging modalities in the evaluation of patients with dementia.

Original languageEnglish (US)
Pages (from-to)1339-1342
Number of pages4
JournalNeurology
Volume47
Issue number5
StatePublished - Nov 1996

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Alzheimer Disease
Perfusion
Echo-Planar Imaging
Dementia
Radio
Occipital Lobe
Functional Neuroimaging
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sandson, T. A., O'Connor, M., Sperling, R. A., Edelman, R. R., & Warach, S. (1996). Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report. Neurology, 47(5), 1339-1342.

Noninvasive perfusion MRI in Alzheimer's disease : A preliminary report. / Sandson, T. A.; O'Connor, M.; Sperling, R. A.; Edelman, R. R.; Warach, S.

In: Neurology, Vol. 47, No. 5, 11.1996, p. 1339-1342.

Research output: Contribution to journalArticle

Sandson, TA, O'Connor, M, Sperling, RA, Edelman, RR & Warach, S 1996, 'Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report', Neurology, vol. 47, no. 5, pp. 1339-1342.
Sandson TA, O'Connor M, Sperling RA, Edelman RR, Warach S. Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report. Neurology. 1996 Nov;47(5):1339-1342.
Sandson, T. A. ; O'Connor, M. ; Sperling, R. A. ; Edelman, R. R. ; Warach, S. / Noninvasive perfusion MRI in Alzheimer's disease : A preliminary report. In: Neurology. 1996 ; Vol. 47, No. 5. pp. 1339-1342.
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