Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model

Kwang Hyun Song, Chulhong Kim, Claire M. Cobley, Younan Xia, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Sentinel lymph node biopsy (SLNB) has been widely performed and become the standard procedure for axillary staging in breast cancer patients. In current SLNB, identification of SLNs is prerequisite, and blue dye and/or radioactive colloids are clinically used for mapping. However, these methods are still intraoperative, and especially radioactive colloids based method is ionizing. As a result, SLNB is generally associated with ill side effects. In this study, we have proposed near-infrared Au nanocages as a new tracer for noninvasive and nonionizing photoacoustic (PA) SLN mapping in a rat model as a step toward clinical applications. Au nanocages have great features: biocompatibility, easy surface modification for biomarker, a tunable surface plasmon resonance (SPR) which allows for peak absorption to be optimized for the laser being used, and capsule-type drug delivery. Au nanocage-enhanced photoacoustic imaging has the potential to be adjunctive to current invasive SLNB for preoperative axillary staging in breast cancer patients.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7177
DOIs
StatePublished - 2009
EventPhotons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States
Duration: Jan 25 2009Jan 28 2009

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2009
CountryUnited States
CitySan Jose, CA
Period1/25/091/28/09

Fingerprint

Radioactive tracers
Photoacoustic effect
Biopsy
lymphatic system
rats
tracers
Rats
Colloids
Vertex of a graph
Breast Cancer
breast
colloids
cancer
Photoacoustic Imaging
Surface Modification
Drug Delivery
Surface Plasmon
biomarkers
Biomarkers
Surface plasmon resonance

Keywords

  • Mapping
  • Nanocages
  • Photoacoustic
  • Sentinel lymph node

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Song, K. H., Kim, C., Cobley, C. M., Xia, Y., & Wang, L. V. (2009). Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7177). [71772L] https://doi.org/10.1117/12.809676

Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model. / Song, Kwang Hyun; Kim, Chulhong; Cobley, Claire M.; Xia, Younan; Wang, Lihong V.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7177 2009. 71772L.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Song, KH, Kim, C, Cobley, CM, Xia, Y & Wang, LV 2009, Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7177, 71772L, Photons Plus Ultrasound: Imaging and Sensing 2009, San Jose, CA, United States, 1/25/09. https://doi.org/10.1117/12.809676
Song KH, Kim C, Cobley CM, Xia Y, Wang LV. Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7177. 2009. 71772L https://doi.org/10.1117/12.809676
Song, Kwang Hyun ; Kim, Chulhong ; Cobley, Claire M. ; Xia, Younan ; Wang, Lihong V. / Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7177 2009.
@inproceedings{5b7444bca0c14e879f5b58f3e435dfe4,
title = "Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model",
abstract = "Sentinel lymph node biopsy (SLNB) has been widely performed and become the standard procedure for axillary staging in breast cancer patients. In current SLNB, identification of SLNs is prerequisite, and blue dye and/or radioactive colloids are clinically used for mapping. However, these methods are still intraoperative, and especially radioactive colloids based method is ionizing. As a result, SLNB is generally associated with ill side effects. In this study, we have proposed near-infrared Au nanocages as a new tracer for noninvasive and nonionizing photoacoustic (PA) SLN mapping in a rat model as a step toward clinical applications. Au nanocages have great features: biocompatibility, easy surface modification for biomarker, a tunable surface plasmon resonance (SPR) which allows for peak absorption to be optimized for the laser being used, and capsule-type drug delivery. Au nanocage-enhanced photoacoustic imaging has the potential to be adjunctive to current invasive SLNB for preoperative axillary staging in breast cancer patients.",
keywords = "Mapping, Nanocages, Photoacoustic, Sentinel lymph node",
author = "Song, {Kwang Hyun} and Chulhong Kim and Cobley, {Claire M.} and Younan Xia and Wang, {Lihong V.}",
year = "2009",
doi = "10.1117/12.809676",
language = "English (US)",
volume = "7177",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model

AU - Song, Kwang Hyun

AU - Kim, Chulhong

AU - Cobley, Claire M.

AU - Xia, Younan

AU - Wang, Lihong V.

PY - 2009

Y1 - 2009

N2 - Sentinel lymph node biopsy (SLNB) has been widely performed and become the standard procedure for axillary staging in breast cancer patients. In current SLNB, identification of SLNs is prerequisite, and blue dye and/or radioactive colloids are clinically used for mapping. However, these methods are still intraoperative, and especially radioactive colloids based method is ionizing. As a result, SLNB is generally associated with ill side effects. In this study, we have proposed near-infrared Au nanocages as a new tracer for noninvasive and nonionizing photoacoustic (PA) SLN mapping in a rat model as a step toward clinical applications. Au nanocages have great features: biocompatibility, easy surface modification for biomarker, a tunable surface plasmon resonance (SPR) which allows for peak absorption to be optimized for the laser being used, and capsule-type drug delivery. Au nanocage-enhanced photoacoustic imaging has the potential to be adjunctive to current invasive SLNB for preoperative axillary staging in breast cancer patients.

AB - Sentinel lymph node biopsy (SLNB) has been widely performed and become the standard procedure for axillary staging in breast cancer patients. In current SLNB, identification of SLNs is prerequisite, and blue dye and/or radioactive colloids are clinically used for mapping. However, these methods are still intraoperative, and especially radioactive colloids based method is ionizing. As a result, SLNB is generally associated with ill side effects. In this study, we have proposed near-infrared Au nanocages as a new tracer for noninvasive and nonionizing photoacoustic (PA) SLN mapping in a rat model as a step toward clinical applications. Au nanocages have great features: biocompatibility, easy surface modification for biomarker, a tunable surface plasmon resonance (SPR) which allows for peak absorption to be optimized for the laser being used, and capsule-type drug delivery. Au nanocage-enhanced photoacoustic imaging has the potential to be adjunctive to current invasive SLNB for preoperative axillary staging in breast cancer patients.

KW - Mapping

KW - Nanocages

KW - Photoacoustic

KW - Sentinel lymph node

UR - http://www.scopus.com/inward/record.url?scp=66249103980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66249103980&partnerID=8YFLogxK

U2 - 10.1117/12.809676

DO - 10.1117/12.809676

M3 - Conference contribution

AN - SCOPUS:66249103980

VL - 7177

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -