Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model

Kwang Hyun Song, Chulhong Kim, Claire M. Cobley, Younan Xia, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Sentinel lymph node biopsy (SLNB) has been widely performed and become the standard procedure for axillary staging in breast cancer patients. In current SLNB, identification of SLNs is prerequisite, and blue dye and/or radioactive colloids are clinically used for mapping. However, these methods are still intraoperative, and especially radioactive colloids based method is ionizing. As a result, SLNB is generally associated with ill side effects. In this study, we have proposed near-infrared Au nanocages as a new tracer for noninvasive and nonionizing photoacoustic (PA) SLN mapping in a rat model as a step toward clinical applications. Au nanocages have great features: biocompatibility, easy surface modification for biomarker, a tunable surface plasmon resonance (SPR) which allows for peak absorption to be optimized for the laser being used, and capsule-type drug delivery. Au nanocage-enhanced photoacoustic imaging has the potential to be adjunctive to current invasive SLNB for preoperative axillary staging in breast cancer patients.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7177
DOIs
StatePublished - 2009
EventPhotons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States
Duration: Jan 25 2009Jan 28 2009

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2009
CountryUnited States
CitySan Jose, CA
Period1/25/091/28/09

Keywords

  • Mapping
  • Nanocages
  • Photoacoustic
  • Sentinel lymph node

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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  • Cite this

    Song, K. H., Kim, C., Cobley, C. M., Xia, Y., & Wang, L. V. (2009). Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7177). [71772L] https://doi.org/10.1117/12.809676