Noninvasive Staging of Kidney Dysfunction Enabled by Renal-Clearable Luminescent Gold Nanoparticles

Mengxiao Yu, Jiancheng Zhou, Bujie Du, Xuhui Ning, Craig Authement, Leah Gandee, Payal Kapur, Jer Tsong Hsieh, Jie Zheng

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

As a "silent killer", kidney disease is often hardly detected at an early stage but can cause lethal kidney failure later on. Thus, a preclinical imaging technique that can readily differentiate between the stages of kidney dysfunction is highly desired for improving our fundamental understanding of kidney disease progression. Herein, we report that in vivo fluorescence imaging, enabled by renal-clearable near-infrared-emitting gold nanoparticles, can noninvasively detect kidney dysfunction, report on the dysfunctional stages, and even reveal adaptive function in a mouse model of unilateral obstructive nephropathy, which cannot be diagnosed with routine kidney function markers. These results demonstrate that low-cost fluorescence kidney functional imaging is highly sensitive and useful for the longitudinal, noninvasive monitoring of kidney dysfunction progression in preclinical research.

Original languageEnglish (US)
Pages (from-to)2787-2791
Number of pages5
JournalAngewandte Chemie - International Edition
Volume55
Issue number8
DOIs
StatePublished - Feb 18 2016

Keywords

  • fluorescence imaging
  • imaging agents
  • kidney disease
  • kidney dysfunction
  • nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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