Nonlinear dynamics of seizure prediction in a rodent model of epilepsy

Levi B. Good, Shivkumar Sabesan, Steven T. Marsh, Konstantinos Tsakalis, David M. Treiman, Leon D. Iasemidis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Epilepsy is a dynamical disorder with intermittent crises (seizures) that until recently were considered unpredictable. In this study, we investigated the predictability of epileptic seizures in chronically epileptic rats as a first step towards a subsequent timely intervention for seizure control. We look at the epileptic brain as a nonlinear complex system that undergoes spatio-temporal state transitions and the Lyapunov exponents as indices of its stability. We estimated the spatial synchronization or desynchronization of the maximum short-term Lyapunov exponents (STLmax, approximate measures of chaos) among multiple brain sites over days of electroencephalographic (EEG) recordings from 5 rats that had developed chronic epilepsy according to the lithium pilocarpine rodent model of epilepsy. We utilized this synchronization of EEG dynamics for the construction of a robust seizure prediction algorithm. The parameters of the algorithm were optimized using receiver operator curves (ROCs) on training EEG datasets from each rat for the algorithm to provide maximum sensitivity and specificity in the prediction of their seizures. The performance of the algorithm was then tested on long-term testing EEG datasets per rat. The thus optimized prediction algorithm on the testing datasets over all rats yielded a seizure prediction mean sensitivity of 85.9%, specificity of 0.180 false predictions per hour, and prediction time of 67.6 minutes prior to a seizure onset. This study provides evidence that prediction of seizures is feasible through analysis of the EEG within the framework of nonlinear dynamics, and thus paves the way for just-in-time pharmacological or physiological interventions to abort seizures tens of minutes before their occurrence.

Original languageEnglish (US)
Pages (from-to)411-434
Number of pages24
JournalNonlinear Dynamics, Psychology, and Life Sciences
Volume14
Issue number4
StatePublished - Oct 2010

Fingerprint

Epilepsy
Nonlinear Dynamics
Rats
Prediction
Lyapunov Exponent
Specificity
Brain
Model
Synchronization
Desynchronization
Testing
Predictability
State Transition
Rodentia
Chaos theory
Mathematical operators
Disorder
Large scale systems
Complex Systems
Chaos

Keywords

  • Dynamic synchronization
  • EEG
  • Epilepsy
  • Lyapunov exponents
  • Seizure prediction

ASJC Scopus subject areas

  • Applied Mathematics

Cite this

Good, L. B., Sabesan, S., Marsh, S. T., Tsakalis, K., Treiman, D. M., & Iasemidis, L. D. (2010). Nonlinear dynamics of seizure prediction in a rodent model of epilepsy. Nonlinear Dynamics, Psychology, and Life Sciences, 14(4), 411-434.

Nonlinear dynamics of seizure prediction in a rodent model of epilepsy. / Good, Levi B.; Sabesan, Shivkumar; Marsh, Steven T.; Tsakalis, Konstantinos; Treiman, David M.; Iasemidis, Leon D.

In: Nonlinear Dynamics, Psychology, and Life Sciences, Vol. 14, No. 4, 10.2010, p. 411-434.

Research output: Contribution to journalArticle

Good, LB, Sabesan, S, Marsh, ST, Tsakalis, K, Treiman, DM & Iasemidis, LD 2010, 'Nonlinear dynamics of seizure prediction in a rodent model of epilepsy', Nonlinear Dynamics, Psychology, and Life Sciences, vol. 14, no. 4, pp. 411-434.
Good LB, Sabesan S, Marsh ST, Tsakalis K, Treiman DM, Iasemidis LD. Nonlinear dynamics of seizure prediction in a rodent model of epilepsy. Nonlinear Dynamics, Psychology, and Life Sciences. 2010 Oct;14(4):411-434.
Good, Levi B. ; Sabesan, Shivkumar ; Marsh, Steven T. ; Tsakalis, Konstantinos ; Treiman, David M. ; Iasemidis, Leon D. / Nonlinear dynamics of seizure prediction in a rodent model of epilepsy. In: Nonlinear Dynamics, Psychology, and Life Sciences. 2010 ; Vol. 14, No. 4. pp. 411-434.
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