TY - JOUR
T1 - Nonsteroidal anti-inflammatory drug gastrointestinal toxicity
AU - Cryer, Byron
PY - 1999/11/10
Y1 - 1999/11/10
N2 - Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently the most widely used class of therapeutic agents. By inhibiting cyclooxygenase (COX) and reducing gastrointestinal prostaglandins, they provide effective analgesia and suppress inflammation in a variety of conditions. However, through the same mechanism of COX inhibition, they also cause significant gastrointestinal toxicity. One of the most common methods to reduce NSAID- induced gastrointestinal toxicity has been to co-prescribe prophylactic therapies such as acid-reducing agents or the synthetic prostaglandin analogue, misoprostol. More recently safer NSAIDs, such as the COX-2 specific NSAIDs or the nitric oxide-releasing NSAIDs, have been developed or are currently in development. This article reviews mechanisms of NSAID-induced gastrointestinal toxicity. Also reviewed are data on the gastrointestinal consequences of the prophylactic co-therapies, COX-2 specific NSAIDs and nitric oxide-releasing NSAIDs.
AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently the most widely used class of therapeutic agents. By inhibiting cyclooxygenase (COX) and reducing gastrointestinal prostaglandins, they provide effective analgesia and suppress inflammation in a variety of conditions. However, through the same mechanism of COX inhibition, they also cause significant gastrointestinal toxicity. One of the most common methods to reduce NSAID- induced gastrointestinal toxicity has been to co-prescribe prophylactic therapies such as acid-reducing agents or the synthetic prostaglandin analogue, misoprostol. More recently safer NSAIDs, such as the COX-2 specific NSAIDs or the nitric oxide-releasing NSAIDs, have been developed or are currently in development. This article reviews mechanisms of NSAID-induced gastrointestinal toxicity. Also reviewed are data on the gastrointestinal consequences of the prophylactic co-therapies, COX-2 specific NSAIDs and nitric oxide-releasing NSAIDs.
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U2 - 10.1097/00001574-199911000-00004
DO - 10.1097/00001574-199911000-00004
M3 - Article
C2 - 17023993
AN - SCOPUS:0032706286
SN - 0267-1379
VL - 15
SP - 473
EP - 480
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 6
ER -