Nonthyroidal control of metabolism after burn injury: Possible role of glucagon

George M. Vaughan, Richard A. Becker, Roger H Unger, Michael G. Ziegler, Theresa M. Siler-Khodr, Basil A. Pruitt, Arthur D. Mason

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The endocrine basis for control of metabolism in nonthyroidal illness is not yet understood. Burn injury is associated with reduced serum concentrations of thyroid hormones and with resting hypermetabolism. One index of severity is total burn size (TBS, % body surface). After overnight fasting and recumbency, resting metabolic rate (MR, O2 consumption) was measured weekly and plasma was sampled for determination of glucose, total cholesterol, triglycerides, insulin, glucagon, somatostatin, growth hormone, norepinephrine, epinephrine, and cortisol in 28 burned men, 17-23 years old, TBS 2%-85%, including 8 controls with minimal injury (TBS ≤ 7.5%). MR was elevated in proportion to burn size mainly in the first week then declined toward normal. Growth hormone was not changed. Two multiple regression analyses (validated by random partitioning of data) determined which plasma variables independently reflected residual variation in MR: without TBS entered as a variable, high MR was associated with elevated glucose, cortisol, and glucagon, and low cholesterol (cumulative r2 = 0.79); with TBS entered, high MR was associated with greater TBS, elevated norepinephrine, and again high glucagon and low cholesterol (r2 = 0.81). Resting metabolism after burn injury is controlled not by the thyroid but may be controlled by a set of antiinsulin hormones that does not include growth hormone, but possibly includes glucagon.

Original languageEnglish (US)
Pages (from-to)637-641
Number of pages5
JournalMetabolism
Volume34
Issue number7
DOIs
StatePublished - 1985

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Glucagon
Growth Hormone
Cholesterol
Wounds and Injuries
Hydrocortisone
Norepinephrine
Glucose
Basal Metabolism
Body Size
Somatostatin
Thyroid Hormones
Epinephrine
Fasting
Thyroid Gland
Triglycerides
Regression Analysis
Hormones
Insulin
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Vaughan, G. M., Becker, R. A., Unger, R. H., Ziegler, M. G., Siler-Khodr, T. M., Pruitt, B. A., & Mason, A. D. (1985). Nonthyroidal control of metabolism after burn injury: Possible role of glucagon. Metabolism, 34(7), 637-641. https://doi.org/10.1016/0026-0495(85)90091-5

Nonthyroidal control of metabolism after burn injury : Possible role of glucagon. / Vaughan, George M.; Becker, Richard A.; Unger, Roger H; Ziegler, Michael G.; Siler-Khodr, Theresa M.; Pruitt, Basil A.; Mason, Arthur D.

In: Metabolism, Vol. 34, No. 7, 1985, p. 637-641.

Research output: Contribution to journalArticle

Vaughan, GM, Becker, RA, Unger, RH, Ziegler, MG, Siler-Khodr, TM, Pruitt, BA & Mason, AD 1985, 'Nonthyroidal control of metabolism after burn injury: Possible role of glucagon', Metabolism, vol. 34, no. 7, pp. 637-641. https://doi.org/10.1016/0026-0495(85)90091-5
Vaughan, George M. ; Becker, Richard A. ; Unger, Roger H ; Ziegler, Michael G. ; Siler-Khodr, Theresa M. ; Pruitt, Basil A. ; Mason, Arthur D. / Nonthyroidal control of metabolism after burn injury : Possible role of glucagon. In: Metabolism. 1985 ; Vol. 34, No. 7. pp. 637-641.
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