Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures

Nicholas W. Seeds, Alfred G. Gilman

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Norepinephrine causes a four- to sixfold increase in the intracellular level of cyclic AMP (adenosine 3′,5′-monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain. The cyclic AMP level of adult brain is increased by norepinephrine; however, embryonic mouse brain does not show a cyclic AMP response. The aggregate cultures thus demonstrate an event of differentiation very similar to that seen in vivo.

Original languageEnglish (US)
Pages (from-to)292
Number of pages1
JournalScience
Volume174
Issue number4006
StatePublished - 1971

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Adenosine
Norepinephrine
Cell Culture Techniques
Brain

ASJC Scopus subject areas

  • General

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Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures. / Seeds, Nicholas W.; Gilman, Alfred G.

In: Science, Vol. 174, No. 4006, 1971, p. 292.

Research output: Contribution to journalArticle

Seeds, Nicholas W. ; Gilman, Alfred G. / Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures. In: Science. 1971 ; Vol. 174, No. 4006. pp. 292.
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