Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures

Nicholas W. Seeds, Alfred G. Gilman

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Norepinephrine causes a four- to sixfold increase in the intracellular level of cyclic AMP (adenosine 3′,5′-monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain. The cyclic AMP level of adult brain is increased by norepinephrine; however, embryonic mouse brain does not show a cyclic AMP response. The aggregate cultures thus demonstrate an event of differentiation very similar to that seen in vivo.

Original languageEnglish (US)
Number of pages1
JournalScience
Volume174
Issue number4006
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures'. Together they form a unique fingerprint.

  • Cite this