Abstract
Xenotransplantation between discordant species leads to a hyperacute rejection mediated by natural antibodies, both of the IgG and IgM isotypes, activation of complement and endothelial cell activation. The combination of these mechanisms leads to a transplant survival of minutes to a few hours. Polyclonal human immunoglobulins for intravenous use (IVIg) from normal donors have proved effective in a number of antibody-mediated disorders, as well as in inflammatory disorders. We demonstrate that administration of IVIg in a guinea pig to rat model of cardiac xenografting can effectively delay hyperacute rejection. This effect is mediated by the F(ab')2 fragments of IVIg, and is correlated to an and-complementary activity.
Original language | English (US) |
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Pages (from-to) | 122-126 |
Number of pages | 5 |
Journal | Clinical and Experimental Immunology |
Volume | 110 |
Issue number | 1 |
DOIs | |
State | Published - 1997 |
Keywords
- Complement
- IVIg
- Xenotransplantation
ASJC Scopus subject areas
- General Medicine